Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

被引：98
作者：
Zhao, Yingke [1 ,2 ]
Liu, Yue [1 ]
Chen, Keji [1 ]
机构：
[1] China Acad Chinese Med Sci, Xiyuan Hosp, Cardiovasc Dis Ctr, Beijing, Peoples R China
[2] Univ Hong Kong, Sch Chinese Med, Pokfulam, Hong Kong, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷
基金：
中国国家自然科学基金;
关键词：
INDUCED OXIDATIVE DAMAGE; HEPATIC STELLATE CELLS; SMOOTH-MUSCLE-CELLS; CEREBRAL ISCHEMIA/REPERFUSION; LIGUSTRAZINE INJECTION; DILATED CARDIOMYOPATHY; TRADITIONAL CHINESE; ACTIVE COMPONENT; INTERFERON-GAMMA; ISCHEMIC-STROKE;
D O I：
10.1155/2016/2124638
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tetramethylpyrazine, a natural compound from Ligusticum wallichii (Chuan Xiong), has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystems, especially in cardiovascular, its pharmacological action, clinical application, and the structural modification have attracted broad attention. In this paper its mechanisms of action, the clinical status, and synthetic derivatives will be reviewed briefly.
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页数：9
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