Direct synthesis of indazole derivatives via Rh(iii)-catalyzed C-H activation of phthalazinones and allenes

被引：17

作者：

Yin, Chuanliu ^{[1
]}

Zhong, Tianshuo ^{[1
]}

Zheng, Xiangyun ^{[1
]}

Li, Lianghao ^{[1
]}

Zhou, Jian ^{[1
]}

Yu, Chuanming ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 35期

基金：

中国国家自然科学基金;

关键词：

4+1 ANNULATION; FUNCTIONALIZATION; ALKALOIDS; CINNOLINES; AMIDES; SEEDS;

D O I：

10.1039/d1ob01458g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Rh(iii)-catalyzed annulation of phthalazinones or pyridazinones with various allenes was developed, leading to the formation of indazole derivatives bearing a quaternary carbon in moderate to good yields. The targeted products were synthesized via sequential C-H activation and olefin insertion, followed by beta-hydride elimination and intramolecular cyclization. The synthetic protocol proceeded efficiently with broad functional group tolerance, high atom efficiency and high Z-selectivity. The practicability of this method was proved by synthetic transformation.

引用

页码：7701 / 7705

页数：5

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