Ligands of the transforming growth factor-beta (TGF beta) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes. An equally important challenge is understanding the functional role of signal strength and duration. How are these quantitative aspects of the extracellular signal regulated? How are they then sensed and interpreted, and how do they affect responses?.
机构:
Karolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, SwedenKarolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, Sweden
Reissmann, Eva
Ibanez, Carlos F.
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机构:
Karolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, SwedenKarolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, Sweden
机构:
Karolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, SwedenKarolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, Sweden
Reissmann, Eva
Ibanez, Carlos F.
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, SwedenKarolinska Inst, Div Mol Neurobiol, Dept Neurosci, S-17177 Stockholm, Sweden