TGFβ-SMAD signal transduction:: molecular specificity and functional flexibility

被引:1021
作者
Schmierer, Bernhard [1 ]
Hill, Caroline S. [1 ]
机构
[1] Canc Res UK London Res Inst, Dev Signalling Lab, London WC2A 3PX, England
关键词
D O I
10.1038/nrm2297
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ligands of the transforming growth factor-beta (TGF beta) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes. An equally important challenge is understanding the functional role of signal strength and duration. How are these quantitative aspects of the extracellular signal regulated? How are they then sensed and interpreted, and how do they affect responses?.
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页码:970 / 982
页数:13
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