The use of reversible addition fragmentation chain transfer polymerization for drug delivery systems

被引:33
作者
Gregory, Andrew [1 ]
Stenzel, Martina H. [1 ]
机构
[1] Univ New S Wales, CAMD, Sydney, NSW 2052, Australia
基金
澳大利亚研究理事会;
关键词
core-shell nanoparticles; drug delivery; gene delivery; hydrogel; micelle; polymer therapeutics; RAFT polymerization; CROSS-LINKED MICELLES; LIVING RADICAL POLYMERIZATION; BLOCK-COPOLYMER MICELLES; TRANSFER RAFT POLYMERIZATION; WATER-SOLUBLE (CO)POLYMERS; CORE-SHELL NANOPARTICLES; AVIDIN-BIOTIN TECHNOLOGY; STRUCTURED POROUS FILMS; IN-SITU FORMATION; FUNCTIONAL POLYMERS;
D O I
10.1517/17425247.2011.548381
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Reversible Addition Fragmentation Chain Transfer (RAFT) polymerisation is now an established tool for polymer chemists to create various polymer architectures with precise control over the molecular weight, and to install a variety of different moieties onto the polymer chain ends. Recently, there seems to be a trend of moving polymer science away from the traditional academic focussed research, to instead identifying real-world problems and how these can be solved with the aid of macromolecules. Areas covered: This article has two themes; the synthesis of polymers for polymer therapeutics; and the design of polymer carriers for the physical encapsulation of drugs and genes, which can either be micelles, gels or other core-shell particles. The first part summarizes the avenues polymer chemists have developed by using RAFT polymerization to attach active compounds (such as drugs or proteins) to polymer chains. The second part gives an overview of the possibilities of using polymer nanocarriers (such as micelles, other core-shell nanoparticles, hydrogels and cationic polymers) for drug delivery. Expert opinion: RAFT polymerisation seems to have endless possibilities in terms of macromolecular design, that is once the pitfalls of the process have been considered, which are based on the radical nature of the mechanism. Polymer chemists have explored many synthetic pathways in order to generate a myriad of structures, and to provide proof of concept for their ideas. However, considering the length of time it takes to get a polymer into a clinical trial, attention should be focussed on detailing the biological evaluation of these well-defined structures.
引用
收藏
页码:237 / 269
页数:33
相关论文
共 265 条
  • [61] Experimental requirements for an efficient control of free-radical polymerizations via the reversible addition-fragmentation chain transfer (RAFT) process
    Favier, Arnaud
    Charreyre, Marie-Therese
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2006, 27 (09) : 653 - 692
  • [62] Dynamics of block copolymers: Theory and experiment
    Fredrickson, GH
    Bates, FS
    [J]. ANNUAL REVIEW OF MATERIALS SCIENCE, 1996, 26 : 501 - 550
  • [63] Injectable pH- and Temperature-Responsive Poly(N-isopropylacrylamide-co-propylacrylic acid) Copolymers for Delivery of Angiogenic Growth Factors
    Garbern, Jessica C.
    Hoffman, Allan S.
    Stayton, Patrick S.
    [J]. BIOMACROMOLECULES, 2010, 11 (07) : 1833 - 1839
  • [64] Postpolymerization Modification of Poly(Pentafluorophenyl methacrylate): Synthesis of a Diverse Water-Soluble Polymer Library
    Gibson, Matthew I.
    Froehlich, Eleonore
    Klok, Harm-Anton
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2009, 47 (17) : 4332 - 4345
  • [65] Access to cyclic polystyrenes via a combination of reversible addition fragmentation chain transfer (RAFT) polymerization and click chemistry
    Goldmann, Anja S.
    Quemener, Damien
    Millard, Pierre-Eric
    Davis, Thomas P.
    Stenzel, Martina H.
    Barner-Kowollik, Christopher
    Wuller, Axel H. E.
    [J]. POLYMER, 2008, 49 (09) : 2274 - 2281
  • [66] Surface Modification of Poly(divinylbenzene) Microspheres via Thiol-Ene Chemistry and Alkyne-Azide Click Reactions
    Goldmann, Anja S.
    Walther, Andreas
    Nebhani, Leena
    Joso, Raymond
    Ernst, Dominique
    Loos, Katja
    Barner-Kowollik, Christopher
    Barner, Leonie
    Mueller, Axel H. E.
    [J]. MACROMOLECULES, 2009, 42 (11) : 3707 - 3714
  • [67] A Novel One-Pot Procedure for the Fast and Efficient Conversion of RAFT Polymers into Hydroxy-Functional Polymers
    Gruendling, Till
    Dietrich, Mathias
    Barner-Kowollik, Christopher
    [J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 2009, 62 (08) : 806 - 812
  • [68] Synthesis of Poly(glycidyl methacrylate)-block-Poly(pentafluorostyrene) by RAFT: Precursor to Novel Amphiphilic Poly(glyceryl methacrylate)-block-Poly(pentafluorostyrene)
    Gudipati, Chakravarthy S.
    Tan, Maureen B. H.
    Hussain, Hazrat
    Liu, Ye
    He, Chaobin
    Davis, Thomas P.
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2008, 29 (23) : 1902 - 1907
  • [69] Synthesis of Homopolymers and Copolymers Containing an Active Ester of Acrylic Acid by RAFT: Scaffolds for Controlling Polyvalent Ligand Display
    Gujraty, Kunal V.
    Yanjarappa, Mallinamadugu J.
    Saraph, Arundhati
    Joshi, Amit
    Mogridge, Jeremy
    Kane, Ravi S.
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 46 (21) : 7249 - 7257
  • [70] Shell-cross-linked vesicles synthesized from block copolymers of poly(D,L-lactide) and poly (N-isopropyl acrylamide) as thermoresponsive nanocontainers
    Hales, M
    Barner-Kowollik, C
    Davis, TP
    Stenzel, MH
    [J]. LANGMUIR, 2004, 20 (25) : 10809 - 10817