The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

被引：40

作者：

Yan, Dayun ^{[1
]}

Sherman, Jonathan H. ^{[2
]}

Keidar, Michael ^{[1
]}

机构：

[1] George Washington Univ, Dept Mech & Aerosp Engn, Sci & Engn Hall,800 22nd St NW,Room 3550, Washington, DC 20052 USA

[2] George Washington Univ, Neurol Surg, Foggy Bottom South Pavil,22nd St NW,7th Floor, Washington, DC 20037 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 06期

基金：

美国国家科学基金会;

关键词：

Plasma; cold atmospheric plasma; cancer cells; cancer treatment; reactive nitrogen species; reactive oxygen species; BARRIER DISCHARGE PLASMA; A549 CELL INJURY; NONTHERMAL PLASMA; DEATH; INDUCTION; TUMORS;

D O I：

10.2174/1871520617666170731115233

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

引用

页码：769 / 775

页数：7

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