HIV-Positive-to-HIV-Positive Liver Transplantation

被引：36
作者：
Calmy, A. [1 ]
van Delden, C. [2 ]
Giostra, E. [3 ]
Junet, C.
Rubbia Brandt, L. [4 ]
Yerly, S. [5 ]
Chave, J-P.
Samer, C. [6 ]
Elkrief, L. [3 ]
Vionnet, J. [7 ,8 ]
Berney, T. [3 ]
机构：
[1] Univ Hosp Geneva, HIV Unit, Geneva, Switzerland
[2] Univ Hosp Geneva, Transplant Infect Dis Unit, Geneva, Switzerland
[3] Univ Hosp Geneva, Div Transplantat, Geneva, Switzerland
[4] Univ Hosp Geneva, Div Pathol, Geneva, Switzerland
[5] Univ Hosp Geneva, Virol Lab, Geneva, Switzerland
[6] Univ Hosp Geneva, Div Clin Pharmacol & Toxicol, Geneva, Switzerland
[7] CHU Vaudois, Div Gastroenterol, Lausanne, Switzerland
[8] CHU Vaudois, Div Transplantat, Lausanne, Switzerland
来源：
AMERICAN JOURNAL OF TRANSPLANTATION | 2016年 / 16卷 / 08期
关键词：
clinical research; practice; ethics and public policy; infectious disease; immune deficiency; patient safety; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C; ORGAN DONATION; RECIPIENTS; COINFECTION; CANDIDATES; MORTALITY; SURVIVAL; OUTCOMES; COHORT;
D O I：
10.1111/ajt.13824
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Most countries exclude human immunodeficiency virus (HIV)-positive patients from organ donation because of concerns regarding donor-derived HIV transmission. The Swiss Federal Act on Transplantation has allowed organ transplantation between HIV-positive donors and recipients since 2007. We report the successful liver transplantation from an HIV-positive donor to an HIV-positive recipient. Both donor and recipient had been treated for many years with antiretroviral therapy and harbored multidrug-resistant viruses. Five months after transplantation, HIV viremia remains undetectable. This observation supports the inclusion of appropriate HIV-positive donors for transplants specifically allocated to HIV-positive recipients. The authors report the first liver transplant from an HIV-positive donor to an HIV-positive recipient with a successful outcome at 6 months, and argue that the medical and social advances represented by this case call for legal and political progress. See the editorial from Fishman and Feng on page 2252.
引用
收藏
页码：2473 / 2478
页数：6
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