Protein dynamics from NMR

被引:316
作者
Kay, LE
机构
[1] Univ Toronto, Prot Engn Network Ctr Excellence, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Dept Med Genet, Toronto, ON M5S 1A8, Canada
[3] Univ Toronto, Dept Biochem & Chem, Toronto, ON M5S 1A8, Canada
关键词
D O I
10.1038/755
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the past several years a significant number of new multidimensional NMR methods have been developed to study molecular dynamics spanning a wide range of time scales. Applications involving a large number of biological systems have emerged and correlations with function established. Unique insights are obtained that are not available from structure alone, indicating the importance of dynamics studies for understanding function.
引用
收藏
页码:513 / 517
页数:5
相关论文
共 52 条
[1]   NMR ORDER PARAMETERS AND FREE-ENERGY - AN ANALYTICAL APPROACH AND ITS APPLICATION TO COOPERATIVE CA2+ BINDING BY CALBINDIN-D(9K) [J].
AKKE, M ;
BRUSCHWEILER, R ;
PALMER, AG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (21) :9832-9833
[2]   Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain [J].
Akke, M ;
Liu, J ;
Cavanagh, J ;
Erickson, HP ;
Palmer, AG .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (01) :55-59
[3]   Monitoring macromolecular motions on microsecond to millisecond time scales by R(1)rho-R(1) constant relaxation time NMR spectroscopy [J].
Akke, M ;
Palmer, AG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (04) :911-912
[4]  
ALEXANDRESCU AT, 1998, IN PRESS PROT SCI
[5]   Enhanced protein flexibility caused by a destabilizing amino acid replacement in BPTI [J].
Beeser, SA ;
Goldenberg, DP ;
Oas, TG .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 269 (01) :154-164
[6]   LONG-RANGE MOTIONAL RESTRICTIONS IN A MULTIDOMAIN ZINC-FINGER PROTEIN FROM ANISOTROPIC TUMBLING [J].
BRUSCHWEILER, R ;
LIAO, XB ;
WRIGHT, PE .
SCIENCE, 1995, 268 (5212) :886-889
[7]  
Cordier F, 1996, J BIOMOL NMR, V7, P163, DOI 10.1007/BF00203827
[8]   USING THE MODEL-FREE APPROACH TO INTERPRET C-13 NMR MULTIPLET RELAXATION DATA FROM PEPTIDES AND PROTEINS [J].
DARAGAN, VA ;
MAYO, KH .
JOURNAL OF MAGNETIC RESONANCE SERIES B, 1995, 107 (03) :274-278
[9]   TRIGLYCINE AND DIGLYCINE BACKBONE ROTATIONAL-DYNAMICS INVESTIGATED BY C-13 NMR MULTIPLET RELAXATION AND MOLECULAR-DYNAMICS SIMULATIONS [J].
DARAGAN, VA ;
MAYO, KH .
BIOCHEMISTRY, 1993, 32 (43) :11488-11499
[10]   Carbonyl carbon probe of local mobility in C-13,N-15-enriched proteins using high-resolution nuclear magnetic resonance [J].
Dayie, KT ;
Wagner, G .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (33) :7797-7806