Vacuum alignment in technicolor models provides an attractive origin for the quarks' CP violation and, possibly, a natural solution for the strong-CP problem of QCD. We discuss these topics in this paper. Then we apply them to determine plausible mixing matrices for left and right-handed quarks. These matrices determine the Cabibbo-Kobayashi-Maskawa matrix as well as new mixing angles and phases that are observable in extended technicolor (ETC) and topcolor (TC2) interactions. We determine the contributions of these new interactions to CP-violating and mixing observables in the K-0, B-d and B-s systems. Consistency with mixing and CP violation in the K-0 system requires assuming that ETC interactions are electroweak generation-conserving even if technicolor has a walking gauge coupling. Large ETC gauge boson masses and small intergenerational mixing then result in negligibly small ETC contributions to B-meson mixing and CP violation and to Re(epsilon'/epsilon). We confirm our earlier strong lower bounds on TC2 gauge boson masses from B-d-(B) over bar (d) mixing. We then pay special attention to the possibility that current experiments indicate a deviation from standard model expectations of the values of sin2beta measured in B-d-->J/psiK(S), phiK(S), eta'K-S, and piK(S), studying the ability of TC2 to account for these. We also determine the TC2 contribution to DeltaM(Bs) and to Re(epsilon'/epsilon), and find them to be appreciable.