A pH-controlled one-pot synthesis of gold nanostars by using a zwitterionic protein hydrolysate (gelatin): an enhanced radiosensitization of cancer cells
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作者:
Das, Ram Pada
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Bhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, IndiaBhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Das, Ram Pada
[1
,2
]
Gandhi, Vishwa V.
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Bhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, IndiaBhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Gandhi, Vishwa V.
[1
,2
]
Singh, Beena G.
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Bhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, IndiaBhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Singh, Beena G.
[1
,2
]
Kunwar, Amit
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Bhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, IndiaBhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
Kunwar, Amit
[1
,2
]
机构:
[1] Bhabha Atom Res Ctr, Radiat & Photochem Div, Mumbai 400085, Maharashtra, India
[2] Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India
For the first time, the present study reports that gelatin, a protein hydrolysate, can be used as a stabilizing agent for the green seedless synthesis of gold (Au) nanoparticles of varying shapes (spherical, triangular and star) of identical size (similar to 60 nm). The detailed investigation revealed that the concentration of gelatin and the pH of a reaction mixture primarily dictated the shape of Au nanoparticles. The reaction mixture containing Au-salt (3 mM) and lower concentrations (0.5%) of gelatin at acidic pH (3-6) favoured the formation of anisotropic nanoparticles (star and triangular shaped). On the contrary, the reaction mixture containing similar precursors at basic pH (pH = 9) favoured the formation of isotropic spherical shaped particles. Furthermore, although ascorbic acid as a reducing agent did not play any role in shape determination, it was required for the formation of nanoparticles at lower pH. However, at higher pH, gelatin itself acted as a reducing agent and supported the formation of nanoparticles. Finally, the radio-sensitizing effect of Au nanoparticles was evaluated in human lung cancer cells (A549) in combination with varying absorbed doses (2-8 Gy) of gamma-radiation. This study indicated that the star shaped Au nanoparticles exhibited higher radio-sensitization in comparison to the spherical and triangular shaped Au nanoparticles with a dose modification factor of 0.76.
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Chonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea
Subramaniyan, Sivakumar Allur
Sheet, Sunirmal
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Chonbuk Natl Univ, Coll Agr & Life Sci, Dept Wood Sci & Technol, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea
Sheet, Sunirmal
Vinothkannan, Mohanraj
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Chonbuk Natl Univ, Hydrogen & Fuel Cell Res Ctr, Grad Sch, Dept Energy Storage Convers Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea
Vinothkannan, Mohanraj
Yoo, Dong Jin
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Chonbuk Natl Univ, Hydrogen & Fuel Cell Res Ctr, Grad Sch, Dept Energy Storage Convers Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea
Yoo, Dong Jin
Lee, Yang Soo
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Chonbuk Natl Univ, Coll Agr & Life Sci, Dept Wood Sci & Technol, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea
Lee, Yang Soo
Belal, Shah Ahmed
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Chonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea
Belal, Shah Ahmed
Shim, Kwan Seob
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Chonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Agr & Life Sci, Dept Anim Biotechnol, Jeonju 561756, South Korea