Cancer stem cells, cancer-initiating cells and methods for their detection

被引：62

作者：

Akbari-Birgani, Shiva ^{[1
]}

Paranjothy, Ted ^{[2
]}

Zuse, Anna ^{[3
]}

Janikowski, Tomasz ^{[4
]}

Cieslar-Pobuda, Artur ^{[5
]}

Likus, Wirginia ^{[6
]}

Urasinska, Elzbieta ^{[7
]}

Schweizer, Frank ^{[8
]}

Ghavami, Saeid ^{[9
,10
,13
]}

Kionisch, Thomas ^{[10
]}

Los, Marek J. ^{[11
,12
]}

机构：

[1] IASBS, Fac Biol Sci, Zanjan, Iran

[2] Univ Toronto Mississauga, Inst Management & Innovat, Toronto, ON, Canada

[3] Univ Basel, Hosp Baselland, Dept Surg, Liestal, Switzerland

[4] Univ Silesia, Sch Pharm, Dept Mol Biol Med, Div Lab Med Sosnowiec, Silesia, Poland

[5] Silesian Tech Univ, Inst Automat Control, Gliwice, Poland

[6] Med Univ Silesia, Sch Med Katowice, Dept Anat, Katowice, Poland

[7] Pomeranian Med Univ, Dept Pathol, Szczecin, Poland

[8] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada

[9] Univ Manitoba, Children Hosp Res Inst Manitoba, Winnipeg, MB, Canada

[10] Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB, Canada

[11] LinkoCare Life Sci AB, S-58330 Linkoping, Sweden

[12] Med Univ Silesia, Sch Med, ENT Dept, Katowice, Poland

[13] Shiraz Med Univ, Ctr Hlth Policy Res, Shiraz, Iran

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ACUTE MYELOID-LEUKEMIA; PROSTATE-CANCER; ALDEHYDE DEHYDROGENASE; ANDROGEN INDEPENDENCE; IDENTIFICATION; THERAPY; MARKER; FLUORESCENT; EXPRESSION; TRACKING;

D O I：

10.1016/j.drudis.2016.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cancer stem cell (CSC) hypothesis considers CSCs as the main culprits of tumor initiation, propagation, metastasis and therapy failure. CSCs represent a minority subpopulation of cells within a tumor. Their detection, characterization and monitoring are crucial steps toward a better understanding of the biological roles of these special cells in the development and propagation of tumors which, in turn, improves clinical reasoning and treatment options. Nowadays, in vitro and in vivo assays are available that address the self-renewal and differentiation potential of CSCs, and advanced in vivo molecular imaging technology facilitates the detection and provides an unprecedented in vivo observation platform to study the behavior of CSCs in their natural environment. Here, we provide a brief overview of CSCs and describe modern cellular models and labeling techniques to study and trace CSCs.

引用

页码：836 / 842

页数：7

共 99 条

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