Limonene and Perillyl Alcohol Derivatives: Synthesis and Anticancer Activity

被引：10

作者：

da Silva, Cesar Emiliano Hoffmann ^{[1
]}

Gosmann, Grace ^{[1
]}

de Andrade, Saulo Fernandes ^{[2
]}

机构：

[1] Univ Fed Rio Grande UFRGS, Lab Phytochem & Organ Synth LAFIS, Fac Pharm, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande UFRGS, Pharmaceut Synth Grp PHARSG, Fac Pharm, Porto Alegre, RS, Brazil

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2021年 / 21卷 / 14期

关键词：

Limonene; perillyl alcohol; anticancer; conjugation; hybrid; thiosemicarbazone; carbohydrate; IN-VITRO; ORGANIC-SYNTHESIS; PHOSPHOLIPASE-D; ESSENTIAL OILS; CANCER; MONOTERPENE; INHIBITORS; DRUG; NEO212; THIOSEMICARBAZONES;

D O I：

10.2174/1389557521666210212150504

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Limonene and perillyl alcohol are natural monoterpenes that have attracted the attention of medicinal chemists due to their promising anticancer activities. Considering this, both compounds were explored as scaffolds to obtain various derivatives with anticancer activity. In this review, the data are organized for the first time, with a focus on the synthetic methods and strategies to obtain the derivatives throughout the period from 2000 to 2020. A brief discussion regarding the structure and activity relationships of the most active derivatives, stereoisomers, and their mechanisms of action is presented. Among the active compounds, a series of limonenes with thiosemicarbazone groups and perillyl alcohol hybrids with glycosides or drugs are illustrated. Taking all of this into account, this review may help researchers develop new promising anticancer candidates based on the structures of limonene and perillyl alcohol.

引用

页码：1813 / 1829

页数：17

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