Melatonin in Heart Failure: A Promising Therapeutic Strategy?

被引：44
作者：
Nduhirabandi, Frederic [1 ]
Maarman, Gerald J. [1 ]
机构：
[1] Univ Cape Town, Fac Hlth Sci, Dept Med, Cardioprotect Grp,HICRA, ZA-7935 Cape Town, South Africa
来源：
MOLECULES | 2018年 / 23卷 / 07期
基金：
新加坡国家研究基金会; 欧洲研究理事会;
关键词：
cardiac remodeling; cardioprotection; cardiomyopathy; fibrosis; heart failure; hypertension; ischemic heart disease; melatonin; metabolic syndrome; ISCHEMIA-REPERFUSION INJURY; NOCTURNAL BLOOD-PRESSURE; PULMONARY-HYPERTENSION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; EJECTION FRACTION; RISK-FACTORS; PROTECTS; RATS; ASSOCIATION;
D O I：
10.3390/molecules23071819
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high. This highlights a need for novel paradigms for effective, preventive and curative strategies. Substantial evidence supports the importance of endogenous melatonin in cardiovascular health and the benefits of melatonin supplementation in various cardiac pathologies and cardiometabolic disorders. Melatonin plays a crucial role in major pathological processes associated with heart failure including ischemic injury, oxidative stress, apoptosis, and cardiac remodeling. In this review, available evidence for the role of melatonin in heart failure is discussed. Current challenges and possible limitations of using melatonin in heart failure are also addressed. While few clinical studies have investigated the role of melatonin in the context of heart failure, current findings from experimental studies support the potential use of melatonin as preventive and adjunctive curative therapy in heart failure.
引用
收藏
页数：18
相关论文
共 144 条
[1]   Insulin Resistance: Metabolic Mechanisms and Consequences in the Heart [J].
Abel, E. Dale ;
O'Shea, Karen M. ;
Ramasamy, Ravichandran .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (09) :2068-2076
[2]   Extrapineal melatonin: sources, regulation, and potential functions [J].
Acuna-Castroviejo, Dario ;
Escames, Germaine ;
Venegas, Carmen ;
Diaz-Casado, Maria E. ;
Lima-Cabello, Elena ;
Lopez, Luis C. ;
Rosales-Corral, Sergio ;
Tan, Dun-Xian ;
Reiter, Russel J. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (16) :2997-3025
[3]   Scientific Opinion on the substantiation of a health claim related to melatonin and reduction of sleep onset latency (ID 1698, 1780, 4080) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J].
Agostoni, Carlo ;
Bresson, Jean-Louis ;
Fairweather-Tait, Susan ;
Flynn, Albert ;
Golly, Ines ;
Korhonen, Hannu ;
Lagiou, Pagona ;
Lovik, Martinus ;
Marchetti, Rosangela ;
Martin, Ambroise ;
Moseley, Bevan ;
Neuhauser-Berthold, Monika ;
Przyrembel, Hildegard ;
Salminen, Seppo ;
Sanz, Yolanda ;
Strain, Sean ;
Strobel, Stephan ;
Tetens, Inge ;
Tome, Daniel ;
van Loveren, Hendrik ;
Verhagen, Hans .
EFSA JOURNAL, 2011, 9 (06)
[4]   Melatonin and cryptochrome 2 in metabolic syndrome patients with or without diabetes: a cross-sectional study [J].
Al-Sarraf, Ibrahim Abdul Kareem ;
Kasabri, Violet ;
Akour, Amal ;
Naffa, Randa .
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2018, 35 (02)
[5]   Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis [J].
Amin, Ali H. ;
El-Missiry, Mohamed A. ;
Othman, Azza I. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 747 :166-173
[6]   Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism [J].
An, Rui ;
Zhao, Lei ;
Xi, Cong ;
Li, Haixun ;
Shen, Guohong ;
Liu, Haixiao ;
Zhang, Shumiao ;
Sun, Lijun .
BASIC RESEARCH IN CARDIOLOGY, 2016, 111 (01) :1-15
[7]   The Safety of Melatonin in Humans [J].
Andersen, Lars Peter Holst ;
Gogenur, Ismail ;
Rosenberg, Jacob ;
Reiter, Russel J. .
CLINICAL DRUG INVESTIGATION, 2016, 36 (03) :169-175
[8]  
Tenorio FDAM, 2015, REV ASSOC MED BRAS, V61, P269
[9]   Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α [J].
Arany, Zoltan ;
Novikov, Mikhail ;
Chin, Sherry ;
Ma, Yanhong ;
Rosenzweig, Anthony ;
Spiegelman, Bruce M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :10086-10091
[10]   In response to the comments on our recently published paper entitled "on the mechanisms of melatonin in protection of aluminum phosphide cardiotoxicity" [J].
Asghari, Mohammad Hossein ;
Moloudizargari, Milad ;
Abdollahi, Mohammad .
ARCHIVES OF TOXICOLOGY, 2017, 91 (10) :3457-3458
12345678910