Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex

被引：61

作者：

Martel, Guillaume ^{[1
]}

Hevi, Charles ^{[1
]}

Kane-Goldsmith, Noriko ^{[2
]}

Shumyatsky, Gleb P. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA

[2] Ctr Collaborat Neurosci, Piscataway, NJ 08854 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2011年 / 223卷 / 01期

关键词：

Spatial memory; Social recognition; Object recognition; Perirhinal cortex; Hippocampus; SYNAPTICALLY RELEASED ZINC; LONG-TERM POTENTIATION; DORSAL HIPPOCAMPUS; SPATIAL MEMORY; LEARNED FEAR; MICE; LESIONS; RATS; RECOGNITION; RECEPTORS;

D O I：

10.1016/j.bbr.2011.04.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Since zinc transporter ZnT3 is localized to the hippocampus and perirhinal cortex, we used ZnT3 knockout mice (KO) to analyze the role of ZnT3 in memory and behavior dependent on these brain regions. ZnT3KO mice were normal in initial learning in the standard water maze but had difficulty finding a second platform location. The mutants showed increased social interaction but were deficient in social and object recognition memory. These data suggest that ZnT3 is involved in certain types of spatial memory and behavior dependent on the hippocampus and perirhinal cortex. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：233 / 238

页数：6

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