Recent Advances on Polyoxometalates as Metallodrug Agents for Alzheimer's Disease

被引：4

作者：

Ma, Mengmeng ^{[1
,2
]}

Qu, Xiaogang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Univ Sci & Technol China, Coll Appl Chem & Engn, Hefei 230026, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2020年 / 41卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; Polyoxometalates; beta-Amyloid; AMYLOID-BETA-PEPTIDE; AGGREGATION; NANOPARTICLES; INHIBITORS; CHEMISTRY; DESIGN;

D O I：

10.7503/cjcu20190714

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alzheimer's disease(AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction and memory loss. Although the exact pathogenesis of AD remains unclear, recent evidences have demonstrated that the accumulation and deposition of beta-amyloid peptide(A beta) is a key step in AD pathogenesis. Polyoxometalates(POMs) have the merits of adjustable structures, ease of preparation, and low cost, and thus have shown promising in AD treatment. Hence, recent advances on the POMs as a novel AD metallodrug agent are summarized.

引用

页码：884 / 891

页数：8

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