Sequence-Specific PI Polyamides Make It Possible to Regulate DNA Structure and Function

被引：11

作者：

Bando, Toshikazu ^{[1
]}

Sugiyama, Hiroshi ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

[2] Kyoto Univ, Inst Integrated Cell Mat Sci WPI iCeMS, Sakyo Ku, Kyoto 6068501, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2020年 / 93卷 / 02期

关键词：

PI polyamides; Sequence-specific DNA binding; Regulation of gene expression; G-QUADRUPLEX INDUCTION; MINOR-GROOVE; TRANSCRIPTION; BINDING; RECOGNITION; MOLECULES; DESIGN; MIMICKING; PROMOTER; BIOLOGY;

D O I：

10.1246/bcsj.20190311

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As part of our research over the past 20 years, we have designed sequence-specific DNA-binding ligands that are based on the chemical molecular recognition of bases in nucleic acids. The DNA minor groove-binding molecules, N-methyl-pyrrole (P), and N-methylimidazole (I) polyamides, have been developed to regulate the specific gene expression or high-order DNA structures and visualize specific DNA sequences in cells. The binding properties of PI polyamides were designed to target specific sequences for various chemical applications. The development of PI polyamides may be useful when applying the vast base sequence information obtained from recent genomic-level research.

引用

页码：205 / 215

页数：11

共 50 条

[31] Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer
Chen, Yu
Zubovic, Lorena
Yang, Fan
Godin, Katherine
Pavelitz, Tom
Castellanos, Javier
Macchi, Paolo
Varani, Gabriele
NUCLEIC ACIDS RESEARCH, 2016, 44 (09) : 4381 - 4395
[32] Photocontrollable Sequence-Specific DNA Alkylation by a Pyrrole-Imidazole Polyamide seco-CBI Conjugate
Park, Soyoung
Bando, Toshikazu
Shinohara, Ken-ichi
Nishijima, Shigeki
Sugiyama, Hiroshi
BIOCONJUGATE CHEMISTRY, 2011, 22 (02) : 120 - 124
[33] Nanoscale programmable sequence-specific patterning of DNA scaffolds using RecA protein
Sharma, R.
Davies, A. G.
Waelti, C.
NANOTECHNOLOGY, 2012, 23 (36)
[34] Identification of Protein Cofactors Necessary for Sequence-specific Plasmid DNA Nuclear Import
Miller, Aaron M.
Munkonge, Felix M.
Alton, Eric W. F. W.
Dean, David A.
MOLECULAR THERAPY, 2009, 17 (11) : 1897 - 1903
[35] The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals
Watson, Lisa C.
Kuchenbecker, Kristopher M.
Schiller, Benjamin J.
Gross, John D.
Pufall, Miles A.
Yamamoto, Keith R.
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (07) : 876 - +
[36] Gold-Nanoparticle-Based Multicolor Nanobeacons for Sequence-Specific DNA Analysis
Song, Shiping
Liang, Zhiqiang
Zhang, Juan
Wang, Lihua
Li, Genxi
Fan, Chunhai
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (46) : 8670 - 8674
[37] Influence of Quasi-Specific Sites on Kinetics of Target DNA Search by a Sequence-Specific DNA-Binding Protein
Kemme, Catherine A.
Esadze, Alexandre
Iwahara, Junji
BIOCHEMISTRY, 2015, 54 (44) : 6684 - 6691
[38] Novel genosensor for probing DNA mismatches and UV-induced DNA damage: Sequence-specific recognition
Nair, Sindhu
El-Yazbi, Amira F.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 233
[39] Sequence-specific cleavage of the RNA strand in DNA-RNA hybrids by the fusion of ribonuclease H with a zinc finger
Sulej, Agata A.
Tuszynska, Irina
Skowronek, Krzysztof J.
Nowotny, Marcin
Bujnicki, Janusz M.
NUCLEIC ACIDS RESEARCH, 2012, 40 (22) : 11563 - 11570
[40] DNA minor groove electrostatic potential: influence of sequence-specific transitions of the torsion angle gamma and deoxyribose conformations
Zhitnikov, M. Y.
Shestopalova, A. V.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2017, 35 (15) : 3384 - 3397

← 1 2 3 4 5 →