Remission of C3 glomerulopathy with rituximab as only immunosuppressive therapy

被引:20
作者
Giaime, Philippe [1 ]
Daniel, Laurent [2 ]
Burtey, Stephane [3 ]
机构
[1] Clin Bouchard, Inst Phoceen Nephrol, F-13006 Marseille, France
[2] Univ Aix Marseille, Assistance Publ Hop Marseille, Serv Anatomopathol, Marseille, France
[3] Univ Aix Marseille, Assistance Publ Hop Marseille, Ctr Nephrol & Transplantat Renale, Marseille, France
关键词
C3; glomerulopathy; dense deposit disease; membranoproliferative glomerulonephritis; rituximab; DENSE DEPOSIT DISEASE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; ECULIZUMAB;
D O I
10.5414/CN107945
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
C3 glomerulopathy (C3GP) is a membranoproliferative glomerulonephritis without immunoglobulin deposits. Activation of the alternative pathway of the complement system is central in its pathogenesis. The presence of a C3 nephritic factor (C3Nef), or deficient factor H or I is associated with C3 GP. The treatment is not codified. Here we describe a case of a Caucasian male with a dense deposit disease (a form of C3GP) revealed by nephritic syndrome. C3Nef was present. We treated him with rituximab as the sole immunosuppressive regimen and obtained a complete remission on proteinuria. The effect was sustained at more than 2 years with only two courses of treatment and an excellent tolerance. Rituximab could be proposed as a treatment of C3GP associated with antibodies interfering with complement alternative pathway.
引用
收藏
页码:57 / 60
页数:4
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