Use of Perfluorocarboxylic Acids To Trick Cytochrome P450BM3 into Initiating the Hydroxylation of Gaseous Alkanes

被引：110
|
作者：
Kawakami, Norifumi [1 ]
Shoji, Osami [2 ]
Watanabe, Yoshihito [1 ]
机构：
[1] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[2] Nagoya Univ, Dept Chem, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 23期
关键词：
cytochromes; enzyme catalysis; gaseous alkanes; hydroxylation; perfluorocarboxylic acids; FLAVOCYTOCHROME P-450 BM3; ELECTRON-TRANSFER; ACTIVATION; SUBSTRATE; MONOOXYGENASE;
D O I：
10.1002/anie.201007975
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It has long been believed that the fatty acid hydroxylase wild-type P450BM3 is unable to oxidize gaseous alkanes. However, the simple addition of a perfluorocarboxylic acid as a dummy substrate to initiate the P450BM3 catalytic cycle enabled the efficient hydroxylation of butane and propane (see picture). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5315 / 5318
页数：4
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