Total Intravenous Anesthesia With Propofol Associated or Not With Remifentanil, Ketamine, or S-Ketamine for Laparoscopic Ovariectomy in Female Dogs

Total intravenous anesthesia (TIVA) has been gaining ground in the routine of small animals. This study aimed to evaluate the hemodynamic effects produced by continuous infusion of propofol isolated or associ-ated with ketamine, S-ketamine, or remifentanil in dogs submitted to video laparoscopic ovariectomy. Thirty-two female dogs were randomly assigned to 4 groups (n = 8): G,1 propofol (0.6 mg/kg/min); G2. keta-mine (2 mg/kg followed by 100 mu g/kg/min) and propofol (0.4 mg/kg/min); G3, S-ketamine (1 mg/kg followed by 50 mg/kg/min) and propofol (0.4 mg/kg/min); and G4, remifentanil (1 mu g/kg followed by 0.2 mu g/kg/min) and propofol (0.4 mg/kg/min). All dogs were submitted to the same pre-anesthetic protocol with aceproma-zine (0.1 mg/kg) and meperidine (4 mg/kg) intramuscularly, followed by anesthetic induction with propofol (4 mg/kg). All animals were mechanically ventilated. Heart rate (HR), respiratory rate (f), SpO(2), systolic, dia-stolic and mean arterial blood pressures (SAP, DAP and MAP, respectively), EtCO2, cardiac output (CO), blood glucose and rectal temperature were evaluated in 7 time-points (M0-M7). HR increased throughout the anes-thesia in all groups, except for G4, which showed inferior values. In all groups, EtCO2 increased from M1 to M7. SAP was higher in G1 in relation to G2 in M2 and M3, and G4 in all time points. G4 also obtained the lower values for DAP and MAP, although not inferior to 60 mmHg. CO was unchanged through time and among groups. No groups had hyperglycemia, although glucose levels varied with time. It was concluded that all TIVA protocols showed satisfactory results and hemodynamic stability. (C) 2021 Elsevier Inc. All rights reserved.