WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor

被引：13

作者：

Nara, Hidetoshi ^{[1
]}

Onoda, Tadashi ^{[1
,2
]}

Rahman, Mizanur ^{[1
]}

Araki, Akemi ^{[1
]}

Juliana, Farha Matin ^{[1
]}

Tanaka, Nobuyuki ^{[3
,4
]}

Asao, Hironobu ^{[1
]}

机构：

[1] Yamagata Univ, Fac Med, Dept Immunol, Yamagata 9909585, Japan

[2] Yamagata Univ, Fac Med, Dept Pediat, Yamagata 9909585, Japan

[3] Miyagi Canc Ctr, Res Inst, Div Immunol, Natori, Miyagi 9811293, Japan

[4] Tohoku Univ, Grad Sch Med, Dept Canc Med Sci, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

CELLULAR IMMUNOLOGY | 2011年 / 269卷 / 01期

基金：

日本学术振兴会;

关键词：

WSB-1; IL-21; receptor; Glycosylation; INDUCED STAT INHIBITOR; CYTOKINE RECEPTOR; CELL EXPANSION; GAMMA-CHAIN; T-CELLS; CLONING; DIFFERENTIATION; PROLIFERATION; PROTEIN; FAMILY;

D O I：

10.1016/j.cellimm.2011.03.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-21 (IL-21) is a pleiotropic cytokine that regulates T-cell, B-cell, NK-cell, and myeloid-cell functions. IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain. We identified a novel IL-21R-binding molecule, WSB-1, which contains WD-40 repeats and a SOCS-box domain. WSB-1 associates with the middle part of intracytoplasmic region of IL-21R and enhances the maturation of IL-21R from N-linked glycosylated form to fully glycosylated mature form. Furthermore, WSB-1 moderates IL-21R degradation. Taken together, our present study suggests that WSB-1 has a role in the tuning of the maturation and degradation of IL-21R. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：54 / 59

页数：6

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