The synthesis of naturally occurring peptides and their analogs

被引：2
作者：
Cupido, Tommaso
Tulla-Puche, Judit
Spengler, Jan
Albericio, Fernando
机构：
[1] Univ Barcelona, Inst Biomed Res, E-08028 Barcelona, Spain
[2] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain
来源：
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2007年 / 10卷 / 06期
关键词：
acyl migration; biosynthesis; chemical ligation; cyclic peptides; NRP; pharmaceutical peptide; pseudoproline; resin; solid phase; total synthesis; unnatural amino acids;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The number of peptide-based pharmaceuticals has increased enormously over recent years; some of these peptides are derived from natural sources, and many are large and complex. This review provides an overview of the current state of peptide synthesis methodology, focusing mainly on the synthesis of natural peptides and their analogs.
引用
收藏
页码：768 / 783
页数：16
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