Association Between Heart Rate at Rest and Incident Atrial Fibrillation (from the Copenhagen Electrocardiographic Study)

被引：22

作者：

Skov, Morten W. ^{[1
]}

Bachmann, Troels N. ^{[1
]}

Rasmussen, Peter V. ^{[1
]}

Olesen, Morten S. ^{[1
]}

Pietersen, Adrian ^{[2
]}

Graff, Claus ^{[3
]}

Lind, Bent ^{[2
]}

Struijk, Johannes J. ^{[3
]}

Kober, Lars ^{[4
]}

Haunso, Stig ^{[1
,4
]}

Svendsen, Jesper H. ^{[1
,4
]}

Gerds, Thomas A. ^{[5
]}

Holst, Anders G. ^{[1
]}

Nielsen, Jonas B. ^{[1
,6
,7
]}

机构：

[1] Univ Copenhagen, Rigshosp, Mol Cardiol Lab, Dept Cardiol, Copenhagen, Denmark

[2] Copenhagen Gen Practitioners Lab, Copenhagen, Denmark

[3] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark

[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[5] Univ Copenhagen, Dept Biostat, Copenhagen, Denmark

[6] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2016年 / 118卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

PHYSICAL-ACTIVITY; RISK-FACTORS; FOLLOW-UP; MORTALITY; INTERVAL; DISEASE; STROKE; VALIDATION; VALIDITY; REGISTRY;

D O I：

10.1016/j.amjcard.2016.06.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart rate (HR) at rest is a well-known marker of cardiovascular morbidity and mortality. Results on the association between HR and incident atrial fibrillation (AF) have, however, been conflicting. Using digital electrocardiograms from 281,451 primary care patients, we aimed to describe the association between HR at rest and the hazards of incident AF. Secondary end points were death from all causes and pacemaker implantation. Data on drug use, co-morbidity, and outcomes were collected from nationwide administrative health care registries. During a median follow-up time of 8.4 years, 15,666 subjects were observed to develop AF, of which 1,631 were lone AF. A HR at rest from 30 to 51 beats/min was associated with an adjusted hazard ratio of 1.16 (95% CI 1.06 to 1.27) for AF compared with the reference group (66 to 72 beats/min). From 72 beats/min and upward, the hazard ratio of AF increased in a dose-response manner, reaching an adjusted hazard ratio of 1.36 (95% CI 1.26 to 1.46) for HR between 95 and 120 beats/min. Both for low and high HR, the associations were accentuated for the outcome lone AF (adjusted hazard ratios of 1.48, 95% CI 1.19 to 1.84 and 1.84, 95% CI 1.47 to 2.30 for HR between 30 to 51 and 95 to 120 beats/min, respectively). For death from all causes, the hazard increased almost linearly with increasing HR. A HR at rest from 30 to 51 beats/min was associated with an adjusted hazard ratio of 1.80 (95% CI 1.46 to 2.21) for pacemaker implantation. In conclusion, a U-shaped association was found between HR at rest and incident AF, and this association was strongest for the outcome lone AF. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：708 / 713

页数：6