Fast determination of salbutamol, abused by athletes for doping, in pharmaceuticals and human biological fluids by square wave voltammetry

被引：49

作者：

Goyal, Rajendra N. ^{[1
]}

Oyama, Munetaka ^{[2
]}

Singh, Sudhanshu P. ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Int Innovat Ctr, Div Res Initiat, Kyoto 6158520, Japan

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2007年 / 611卷 / 1-2期

基金：

日本学术振兴会;

关键词：

indium tin oxide; gold nanoparticles; salbutamol; blood plasma; urine; voltammetry;

D O I：

10.1016/j.jelechem.2007.08.014

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The determination of salbutamol, used for doping, has been carried out at nano gold particles modified indium tin oxide (NGITO) electrode using Osteryoung square wave voltammetry. The NGITO electrode exhibited an effective catalytic response towards salbutamol oxidation as compared to bare ITO and bulk gold electrodes. The peak current was also found to be significantly increased. The determination was carried out in phosphate containing electrolyte in the pH range 4.0-10.0 and two well-defined peaks were noticed. The first peak was found to be linearly dependent on concentration of salbutamol in the concentration range 50-2000 ng/ml with a detection limit of 75 ng/ml, whereas the second peak was due to adsorption of product. The product of oxidation corresponding to first peak was found to be C-C linked dimer and peak It was due to strong adsorption of dimer. The proposed method has been applied to determine the concentration of salbutamol in pharmaceutical formulations and human blood plasma and urine samples. A comparison of salbutamol concentration determined by proposed method and GC-MS indicated a good agreement. It is believed that the method is simple, rapid and can be easily used in determining this drug in case of its abuse in doping. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：140 / 148

页数：9

共 34 条

[1] Simultaneous detection of ascorbic acid and uric acid using a fluorosurfactant-modified platinum electrode [J].

Chen, Zuofeng ;

Zu, Yanbing .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2007, 603 (02) :281-286

[2]

Christian G.D., 1962, JELECTROANAL CHEM, V3, P363, DOI [10.1016/0022-0728(62)80012-6, DOI 10.1016/0022-0728(62)80012-6]

[3]

El-Enany N, 2004, CHEM ANAL-WARSAW, V49, P587

[4]

Fang Z.J., 2003, J PHYS CHEM B, V107, P13389

[5] Study on the electrochemical behavior and differential pulse voltammetric determination of rhein using a nanoparticle composite film-modified electrode [J].

Fei, Junjie ;

Peng, Yan ;

Tan, Hongyan ;

Chen, Xiaoming ;

Yang, Jing ;

Li, Junan .

BIOELECTROCHEMISTRY, 2007, 70 (02) :369-374

[6]

Gabiola C, 1996, J MICROCOLUMN SEP, V8, P361, DOI 10.1002/(SICI)1520-667X(1996)8:5<361::AID-MCS6>3.0.CO

[7]

2-#

[8] Effects of inhaled salbutamol in exercising non-asthmatic athletes [J].

Goubault, C ;

Perault, MC ;

Leleu, E ;

Bouquet, S ;

Legros, P ;

Vandel, B ;

Denjean, A .

THORAX, 2001, 56 (09) :675-679

[9] Gold nanoparticles modified indium tin oxide electrode for the simultaneous determination of dopamine and serotonin: Application in pharmaceutical formulations and biological fluids [J].

Goyal, Rajendra N. ;

Gupta, Vinod K. ;

Oyama, Munetaka ;

Bachheti, Neeta .

TALANTA, 2007, 72 (03) :976-983

[10] Electrochemical investigations of biologically active 1-(3-hydroxy-2-pyridyl)-4,4,6-trimethyl-3,4-dihydropyrimidine-2[1H]-thione at pyrolytic graphite electrode [J].

Goyal, Rajendra N. ;

Sondhi, Sham M. ;

Lahoti, Anand M. .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2006, 79 (04) :569-576

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