Metal-organic framework (ZIF-67) interwoven multiwalled carbon nanotubes as a sensing platform for rapid administration of serotonin

Serotonin (SRT), one among the neurotransmitters, is mainly responsible for physiological functions in human body. The effect of changes and intake of SRT can influence higher impact of peoples, thus sensing such compound with more effective and simple technique will be an extreme significance. Zeolite imidazole framework among MOF was constructed with the correlation of multiwall carbon nanotubes (ZIF-67/ MWCNT) as sensor material via simple co-precipitation method. The rationally designed ZIF-67/MWCNT was evaluated for physico-chemical properties analyzed with XRD, XPS and the morphological structures were identified with FESEM. Cyclic voltammetry (CV) and amperometric (IT) technique was initiated for electrochemical detection of SRT. The ZIF-67/MWCNT exhibited a dodecahedron shape and larger surface area as agreed from BET analysis. The electrochemical results obtained at the interfacial site of ZIF-67/MWCNT proved to be more competent with excellent selectivity. SRT was electrochemically detected in human blood serum and urine as real sample analysis. The linear range was 0.049 mM to 800 mM with a lower LOD-7 nM. Moreover, the attained sensitivity was 5.613 mA mM-1 cm2 with excellent repeatability and reproducible behavior. The highly conducting matrix ZIF-67/MWCNT with abundantly accessible sites and higher surface area has gained significant results towards SRT detection. (c) 2021 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.