Addition of Theophylline or Increasing the Dose of Inhaled Corticosteroid in Symptomatic Asthma: A Meta-Analysis of Randomized Controlled Trials

被引：9
作者：
Wang, Yan [1 ]
Lin, Kexiong [1 ]
Wang, Changzheng [1 ]
Liao, Xiuqing [2 ]
机构：
[1] Third Mil Med Univ, Inst Resp Dis, Xinqiao Hosp, Chongqing 400037, Peoples R China
[2] Fuling Cent Hosp, Dept Resp Dis, Chongqing, Peoples R China
来源：
YONSEI MEDICAL JOURNAL | 2011年 / 52卷 / 02期
关键词：
Asthma; theophylline; inhaled corticosteroid; meta-analysis; AIRWAY INFLAMMATION; ADULT ASTHMA; SALMETEROL; SPUTUM; STEROIDS; MODERATE; PROTEIN; SAFETY; RISK;
D O I：
10.3349/ymj.2011.52.2.268
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose: Low-dose theophylline has anti-inflammatory effects. The aim of this study was to evaluate the effects of adding theophylline compared with increasing the dose of inhaled corticosteroid (ICS) on symptomatic asthma. Materials and Methods: The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications. The extracted data were further analyzed by a meta-analysis. Results: Four randomized, controlled, parallel studies were selected. Addition of theophylline produced a greater increase of forced expiratory volume in one second as %predicted (FEV(1)pred) by 2.49% [95% confidence interval (CI) 1.99-3.00; z = 9.70; p < 0.001], compared with increasing the dose of ICS. There was no difference between the two treatments in terms of peak expiratory. flow (PEF). Conclusion: Addition of theophylline to ICS has similar therapeutic effects on improving lung function as increasing the dose of ICS in the treatment of symptomatic asthma.
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收藏
页码：268 / 275
页数：8
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