Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus

被引：2

作者：

Callagy, Sara J.

Kelly, Barbara J.

Fleeton, Marina N.

Sheahan, Brian J.

Galbraith, Sareen E.

Atkins, Gregory J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Moyne Inst Prevent Med, Virus Grp, Dublin 2, Ireland

[2] Natl Univ Ireland Univ Coll Dublin, Vet Sci Ctr, UCD Sch Agr Food Sci & Vet Med, Dublin 4, Ireland

[3] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

VACCINE | 2007年 / 25卷 / 43期

关键词：

rubella virus; Semliki Forest virus vector; multivalent vaccines;

D O I：

10.1016/j.vaccine.2007.08.049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A Semliki Forest virus (SFV) recombinant particle vaccine vector was constructed expressing the viral El and E2 envelope proteins of the RA27/3 vaccine strain of rubella virus. This vector induced high titres of antibody after intramuscular administration to Balb/C mice, both following initial vaccination and a boost 4 weeks later. This occurred for antibody as measured by ELISA and as measured by a latex agglutination test. However, co-administration of similar particles expressing the measles virus H protein and the mumps virus HN protein with the rubella protein expressing vector resulted in reduction of the anti-rubella immune response. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：7481 / 7490

页数：10

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