Podocyte-derived microparticles in IgA nephropathy

被引：14
作者：
Farzamikia, Negin [1 ,2 ]
Baradaran, Behzad [3 ]
Mostafavi, Soroush [1 ,2 ]
Ahmadian, Elham [1 ]
Khatibi, Seyed Mahdi Hosseiniyan [1 ]
Vahed, Sepideh Zununi [1 ]
Ardalan, Mohammadreza [1 ]
机构：
[1] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Med, Immunol Res Ctr, Tabriz, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 141卷
关键词：
Microparticle; Microvesicle; Ectosome; IgA nephropathy; Podocyte; ANGIOTENSIN-II-RECEPTOR; EXTRACELLULAR VESICLES; FACTOR EXPRESSION; ADULT PATIENTS; TNF-ALPHA; MICROVESICLES; PROLIFERATION; ACTIVATION; MEDIATORS; APOPTOSIS;
D O I：
10.1016/j.biopha.2021.111891
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Microparticles are a general term for different types of cell plasma membrane-originated vesicles that are released into the extracellular environment. The paracrine action of these nano-sized vesicles is crucial for intercellular communications through the transfer of diverse lipids, cytosolic proteins, RNA as well as microRNAs. The progression of different diseases influences the composition, occurrence, and functions of these cellderived particles. Podocyte injury has been shown to have an important role in the pathophysiology of many glomerular diseases including IgA nephropathy (IgAN). This review would focus on the possible potential of podocyte-derived microparticles detected in urine to be used as a diagnostic tool in IgAN.
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页数：6
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