The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder

被引：120
作者：
Grande, Iria [1 ,2 ,4 ]
Fries, Gabriel Rodrigo [1 ,2 ]
Kunz, Mauricio [1 ,2 ]
Kapczinski, Flavio [1 ,2 ,3 ]
机构：
[1] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Bipolar Disorder Program, BR-90035903 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Mol Psychiat, BR-90035903 Porto Alegre, RS, Brazil
[3] INCT TM, Natl Inst Translat Med, Porto Alegre, RS, Brazil
[4] Univ Barcelona, Bipolar Disorders Program, Hosp Clin, IDIBAPS,CIBERSAM, Barcelona, Spain
来源：
PSYCHIATRY INVESTIGATION | 2010年 / 7卷 / 04期
关键词：
Bipolar disorder; Brain-derived neurotrophic factor; Neuroplasticity; Stress; Neurotrophins; NEUROTROPHIC FACTOR LEVELS; FACTOR VAL66MET POLYMORPHISM; LITHIUM-TREATED PATIENTS; ONSET MOOD DISORDER; HIPPOCAMPAL VOLUME; PREFRONTAL CORTEX; COGNITIVE IMPAIRMENT; PSYCHOSOCIAL STRESS; DEPRESSIVE EPISODES; EUTHYMIC PATIENTS;
D O I：
10.4306/pi.2010.7.4.243
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The cognitive impairment and neuroanatomical changes that takes place among patients with bipolar disorder (BD) patients has been well described. Recent data suggest that changes in neuroplasticity, cell resilience and connectivity are the main neuropathological findings in BD. Data from differential lines of research converges to the brain-derived neurotrophic factor (BDNF) as an important contributor to the neuroplasticity changes described among BD patients. BDNF serum levels have been shown to be decreased in depressive and manic episodes, returning to normal levels in euthymia. BDNF has also been shown to decrease as the disorder progresses. Moreover, factors that negatively influence the course of BD, such as life stress and trauma have been shown to be associated with a decrease in BDNF serum levels. These findings suggest that BDNF plays a central role in the progression of BD. The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BDNF as a biomarker in BD. Psychiatry Investig 2010;7:243-250
引用
收藏
页码：243 / 250
页数：8
相关论文
共 114 条
[1]   Mouse and rat BDNF gene structure and expression revisited [J].
Aid, Tamara ;
Kazantseva, Anna ;
Piirsoo, Marko ;
Palm, Kaia ;
Timmusk, Tonis .
JOURNAL OF NEUROSCIENCE RESEARCH, 2007, 85 (03) :525-535
[2]   An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia [J].
Altshuler, LL ;
Bartzokis, G ;
Grieder, T ;
Curran, J ;
Jimenez, T ;
Leight, K ;
Wilkins, J ;
Gerner, R ;
Mintz, J .
BIOLOGICAL PSYCHIATRY, 2000, 48 (02) :147-162
[3]   THE GENETICS OF BIPOLAR DISORDER [J].
Barnett, J. H. ;
Smoller, J. W. .
NEUROSCIENCE, 2009, 164 (01) :331-343
[4]   Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder [J].
Bearden, Carrie E. ;
Thompson, Paul M. ;
Dutton, Rebecca A. ;
Frey, Benicio N. ;
Peluso, Marco A. M. ;
Nicoletti, Mark ;
Dierschke, Nicole ;
Hayashi, Kiralee M. ;
Klunder, Andrea D. ;
Glahn, David C. ;
Brambilla, Paolo ;
Sassi, Roberto B. ;
Mallinger, Alan G. ;
Soares, Jair C. .
NEUROPSYCHOPHARMACOLOGY, 2008, 33 (06) :1229-1238
[5]   Greater cortical gray matter density in lithium-treated patients with bipolar disorder [J].
Bearden, Carrie E. ;
Thompson, Paul M. ;
Dalwani, Manish ;
Hayashi, Kiralee M. ;
Lee, Agatha D. ;
Nicoletti, Mark ;
Trakhtenbroit, Michael ;
Glahn, David C. ;
Brambilla, Paolo ;
Sassi, Roberto B. ;
Mallinger, Alan G. ;
Frank, Ellen ;
Kupfer, David J. ;
Soares, Jair C. .
BIOLOGICAL PSYCHIATRY, 2007, 62 (01) :7-16
[6]   Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions [J].
Blum, R ;
Konnerth, A .
PHYSIOLOGY, 2005, 20 :70-78
[7]   Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder [J].
Blumberg, HP ;
Fredericks, C ;
Wang, F ;
Kalmar, JH ;
Spencer, L ;
Papademetris, X ;
Pittman, B ;
Martin, A ;
Peterson, BS ;
Fulbright, RK ;
Krystal, JH .
BIPOLAR DISORDERS, 2005, 7 (06) :570-576
[8]   Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex [J].
Brown, SM ;
Henning, S ;
Wellman, CL .
CEREBRAL CORTEX, 2005, 15 (11) :1714-1722
[9]   Opinion -: Is mood chemistry? [J].
Castrén, E .
NATURE REVIEWS NEUROSCIENCE, 2005, 6 (03) :241-246
[10]   The Role of BDNF and Its Receptors in Depression and Antidepressant Drug Action: Reactivation of Developmental Plasticity [J].
Castren, Eero ;
Rantamaki, Tomi .
DEVELOPMENTAL NEUROBIOLOGY, 2010, 70 (05) :289-297
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