Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages

被引：164

作者：

Stamatiades, Efstathios G. ^{[1
,2
]}

Tremblay, Marie-Eve ^{[3
,4
]}

Bohm, Mathieu ^{[1
,2
,5
,6
]}

Crozet, Lucile ^{[1
,2
,7
]}

Bisht, Kanchan ^{[3
,4
]}

Kao, Daniela ^{[8
]}

Coelho, Carolina ^{[1
,2
]}

Fan, Xiying ^{[1
,2
,9
]}

Yewdell, William T. ^{[1
,2
]}

Davidson, Anne ^{[10
]}

Heeger, Peter S. ^{[11
,12
]}

Diebold, Sandra ^{[13
]}

Nimmerjahn, Falk ^{[8
]}

Geissmann, Frederic ^{[1
,2
,5
,6
,7
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Immunol, 417 East 68th St, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Ludwig Ctr, 417 East 68th St, New York, NY 10065 USA

[3] Univ Laval, Dept Mol Med, Laval, PQ G1V 0A6, Canada

[4] CHU Quebec, Ctr Rech, Axe Neurosci, Quebec City, PQ G1V 4G2, Canada

[5] Kings Coll London, Div Immunol, Infect, London SE1 1UL, England

[6] Kings Coll London, Ctr Mol & Cellular Biol Inflammat Inflammatory Di, London SE1 1UL, England

[7] Weill Cornell Grad Sch Med Sci, 1300 York Ave, New York, NY 10065 USA

[8] Univ Erlangen Nurnberg, Dept Biol, Erwin Rommel Str 3, D-91058 Erlangen, Germany

[9] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, 417 East 68th St, New York, NY 10065 USA

[10] Feinstein Inst Med Res, Manhasset, NY 11030 USA

[11] Mt Sinai Sch Med, Recanati Miller Transplant Inst, Dept Med, New York, NY 10029 USA

[12] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[13] Natl Inst Biol Stand & Controls, Immunotoxicol Team Div, Potters Bar EN6 3QG, Herts, England

来源：

CELL | 2016年 / 166卷 / 04期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

FC-GAMMA RECEPTORS; DENDRITIC CELLS; ARTHUS REACTION; BLOOD-VESSELS; ALBUMIN; IDENTIFICATION; COMPLEXES; MOUSE; MONOCYTES; SYSTEM;

D O I：

10.1016/j.cell.2016.06.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small immune complexes cause type III hypersensitivity reactions that frequently result in tissue injury. The responsible mechanisms, however, remain unclear and differ depending on target organs. Here, we identify a kidney-specific anatomical and functional unit, formed by resident macrophages and peritubular capillary endothelial cells, which monitors the transport of proteins and particles ranging from 20 to 700 kDa or 10 to 200 nm into the kidney interstitium. Kidney-resident macrophages detect and scavenge circulating immune complexes "pumped'' into the interstitium via trans-endothelial transport and trigger a Fc gamma RIV-dependent inflammatory response and the recruitment of monocytes and neutrophils. In addition, Fc gamma RIV and TLR pathways synergistically "super-activate'' kidney macrophages when immune complexes contain a nucleic acid. These data identify a physiological function of tissue-resident kidney macrophages and a basic mechanism by which they initiate the inflammatory response to small immune complexes in the kidney.

引用

页码：991 / 1003

页数：13

共 66 条

[1] Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms [J].