This article studies the relation between religious coping strategies and mental health and also The application of these strategies, especially the cognitive ones in ms(multiple-sclerosis) patients for example: trust in god, praying, philanthropies, believein death and the world after death. The subjects were 50 maleand female ms patients who werein the age of 25-40old. and all were received drug-therapy in one of the Tehrans psychiatric hospitals. The main hypothesis is: patients who are in stressfull conditions like: ms disease but have strong religious believe, and also they apply religious coping strategies, will attain a higher mental health. The instrument was: researcher-made questionair with 13 items in cognitive, avoidance and behavioral domain. its content validity was confirmed by psychiatrists and religious specialists. and its reliability was detected as %80 by test - retest methods in 2 weeks. T test and R correlation were used in this research. Results showed: there is not any significant difference between male/female patients inapplying of religious copings. but it was: there is significant correlation between high religious beliefs and mental health. Patients with high religious tendency have higher mental health.(p<0/5) Inconclusion, we can say that in frustrating situations, some religious beliefs such as: trust in god and having metaphysics beliefs can increase peoples mental health and even help people cope with conditions like death. (C) 2010 Elsevier Ltd. All rights reserved.