Anti-mycobacterial activities of copper(II) complexes. Part II. Lipophilic hydroxypyridinones derived from maltol

被引：10

作者：

Salsbury, Lauren E. ^{[1
]}

Robertson, Katherine N. ^{[2
]}

Flewelling, Andrew J. ^{[3
]}

Li, Hoaxin ^{[3
]}

Geier, Stephen J. ^{[1
]}

Vogels, Christopher M. ^{[1
]}

Gray, Christopher A. ^{[3
,4
]}

Westcott, Stephen A. ^{[1
]}

机构：

[1] Mt Allison Univ, Dept Chem & Biochem, Sackville, NB E4L 1G8, Canada

[2] St Marys Univ, Dept Chem, Halifax, NS E3B 3E3, Canada

[3] Univ New Brunswick, Dept Biol, St John, NB E2L 4L5, Canada

[4] Univ New Brunswick, Dept Chem, Fredericton, NB E3B 5A3, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY | 2015年 / 93卷 / 03期

关键词：

aliphatic amines; anti-mycobacterial; copper; hydroxypyridinones; lipophilic; tuberculosis; IRON CHELATORS; BINDING-PROPERTIES; DESIGN; ION; OXOVANADIUM(IV); CAPREOMYCIN; DERIVATIVES; BEHAVIOR; VANADIUM; CRYSTAL;

D O I：

10.1139/cjc-2014-0426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eight lipophilic 3-hydroxy-4-pyridinones have been prepared from a microwave-mediated reaction along with the corresponding copper(II) complexes. All complexes have been obtained elementally pure and X-ray diffraction studies on two of the copper complexes have confirmed the structure of these compounds. Some of these complexes showed a promising degree of anti-mycobacterial activity against Mycobacterium tuberculosis, where activity seemed to vary by substitution at the pyridinone nitrogen atom.

引用

页码：334 / 340

页数：7

共 51 条

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