TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

被引：41

作者：

Zixin, Ye ^{[1
,2
,3
,4
]}

Lulu, Chen ^{[5
,6
]}

Xiangchang, Zeng ^{[1
,2
,3
,4
]}

Qing, Fang ^{[5
]}

Binjie, Zheng ^{[1
,2
,3
,4
]}

Chunyang, Luo ^{[6
]}

Tai, Rao ^{[1
,2
,3
,4
]}

Dongsheng, Ouyang ^{[1
,2
,3
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Peoples R China

[2] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha, Peoples R China

[3] Minist Educ, Engn Res Ctr Appl Technol Pharmacogen, Changsha, Peoples R China

[4] Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[5] Hunan Key Lab Bioanal Complex Matrix Samples, Changsha, Peoples R China

[6] Affiliated Hosp Xiangnan Univ, Dept Clin Pharm, Chenzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

trimethylamine N-oxide; chronic kidney disease; gut microbiota; targeted TMAO drugs; mechanism; treatment; TRIMETHYLAMINE-N-OXIDE; FLAVIN-CONTAINING MONOOXYGENASE; L-CARNITINE; RENAL-INSUFFICIENCY; PROBIOTIC SUPPLEMENTATION; MICROBIAL-METABOLISM; SECONDARY PREVENTION; CONTRIBUTES; PROGRESSION; FMO3;

D O I：

10.3389/fphar.2022.929262

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The gut microbiota and its metabolites have become a hotspot of recent research. Trimethylamine N-oxide (TMAO) metabolized by the gut microbiota is closely related to many diseases such as cardiovascular disease, chronic kidney disease, type 2 diabetes, etc. Chronic kidney disease (CKD) is an important contributor to morbidity and mortality from non-communicable diseases. Recently, increasing focus has been put on the role of TMAO in the development and progress of chronic kidney disease. The level of TMAO in patients with chronic kidney disease is significantly increased, and a high level of TMAO deteriorates chronic kidney disease. This article describes the relationship between TMAO and chronic kidney disease and the research progress of drugs targeted TMAO, providing a reference for the development of anti-chronic kidney disease drugs targeted TMAO.

引用

页数：12

共 50 条

[41] Osteopontin as a Biomarker in Chronic Kidney Disease
Sinha, Satyesh K.
Mellody, Michael
Carpio, Maria Beatriz
Damoiseaux, Robert
Nicholas, Susanne B.
BIOMEDICINES, 2023, 11 (05)
[42] Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone-Vascular paradox, a therapeutic target, and a biomarker
Williams, Matthew J.
White, Sarah C.
Joseph, Zachary
Hruska, Keith A.
FRONTIERS IN PHYSIOLOGY, 2023, 14
[43] Treatment of asymptomatic hyperuricemia in chronic kidney disease: A new target in an old enemy - A review
Ramirez, Maria Erika G.
Bargman, Joanne M.
JOURNAL OF ADVANCED RESEARCH, 2017, 8 (05) : 551 - 554
[44] Potential Trimethylamine (TMA)-Producing Bacteria in patients with chronic kidney disease undergoing hemodialysis
Alvarenga, Livia
Kemp, Julie Ann
Schultz, Junia
Cardozo, Ludmila F. M. F.
Nakao, Lia S.
Ribeiro-Alves, Marcelo
Rosado, Alexandre
Mafra, Denise
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2025, 57 (02) : 535 - 544
[45] Sympathetic activation secondary to chronic kidney disease: therapeutic target for renal denervation?
de Beus, Esther
de Jager, Rosa
Joles, Jaap A.
Grassi, Guido
Blankestijn, Peter J.
JOURNAL OF HYPERTENSION, 2014, 32 (09) : 1751 - 1761
[46] Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?
Belli, Martina
Barone, Lucy
Longo, Susanna
Prandi, Francesca Romana
Lecis, Dalgisio
Mollace, Rocco
Margonato, Davide
Muscoli, Saverio
Sergi, Domenico
Federici, Massimo
Barilla, Francesco
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)
[47] Circular RNA in Retina: a potential biomarker and therapeutic target
Tian, Huiwen
Zhao, Lu
Li, Hongyang
Huang, Yingxiang
Wang, Yanling
OPHTHALMIC RESEARCH, 2023, 66 (01) : 516 - 528
[48] GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
Naglaa Makram Farag
Mahmoud Mousa
Eman Elsayed
Ahlam Ismeil
Italian Journal of Pediatrics, 49
[49] GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease
Farag, Naglaa Makram
Mousa, Mahmoud
Elsayed, Eman
Ismeil, Ahlam
ITALIAN JOURNAL OF PEDIATRICS, 2023, 49 (01)
[50] Link between gut microbiota dysbiosis and chronic kidney disease
Noce, A.
Marchetti, M.
Marrone, G.
Di Renzo, L.
Di Lauro, M.
Di Daniele, F.
Albanese, M.
Di Daniele, N.
De Lorenzo, A.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2022, 26 (06) : 2057 - 2074

← 1 2 3 4 5 →