TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

被引：54
作者：
Zixin, Ye [1 ,2 ,3 ,4 ]
Lulu, Chen [5 ,6 ]
Xiangchang, Zeng [1 ,2 ,3 ,4 ]
Qing, Fang [5 ]
Binjie, Zheng [1 ,2 ,3 ,4 ]
Chunyang, Luo [6 ]
Tai, Rao [1 ,2 ,3 ,4 ]
Dongsheng, Ouyang [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Peoples R China
[2] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha, Peoples R China
[3] Minist Educ, Engn Res Ctr Appl Technol Pharmacogen, Changsha, Peoples R China
[4] Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[5] Hunan Key Lab Bioanal Complex Matrix Samples, Changsha, Peoples R China
[6] Affiliated Hosp Xiangnan Univ, Dept Clin Pharm, Chenzhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
关键词：
trimethylamine N-oxide; chronic kidney disease; gut microbiota; targeted TMAO drugs; mechanism; treatment; TRIMETHYLAMINE-N-OXIDE; FLAVIN-CONTAINING MONOOXYGENASE; L-CARNITINE; RENAL-INSUFFICIENCY; PROBIOTIC SUPPLEMENTATION; MICROBIAL-METABOLISM; SECONDARY PREVENTION; INDOXYL SULFATE; CONTRIBUTES; PROGRESSION;
D O I：
10.3389/fphar.2022.929262
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The gut microbiota and its metabolites have become a hotspot of recent research. Trimethylamine N-oxide (TMAO) metabolized by the gut microbiota is closely related to many diseases such as cardiovascular disease, chronic kidney disease, type 2 diabetes, etc. Chronic kidney disease (CKD) is an important contributor to morbidity and mortality from non-communicable diseases. Recently, increasing focus has been put on the role of TMAO in the development and progress of chronic kidney disease. The level of TMAO in patients with chronic kidney disease is significantly increased, and a high level of TMAO deteriorates chronic kidney disease. This article describes the relationship between TMAO and chronic kidney disease and the research progress of drugs targeted TMAO, providing a reference for the development of anti-chronic kidney disease drugs targeted TMAO.
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页数：12
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