Cucurbitane-Type Triterpenoids from Momordica charantia

被引：48

作者：

Ma, Jun ^{[1
]}

Whittaker, Paul ^{[1
]}

Keller, Amy C. ^{[2
,3
]}

Mazzola, Eugene P. ^{[1
]}

Pawar, Rahul S. ^{[1
]}

White, Kevin D. ^{[1
]}

Callahan, John H. ^{[1
]}

Kennelly, Edward J. ^{[2
,3
]}

Krynitsky, Alexander J. ^{[1
]}

Rader, Jeanne I. ^{[1
]}

机构：

[1] US FDA, Off Regulatory Sci, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA

[2] CUNY Herbert H Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA

[3] CUNY, Grad Ctr, Bronx, NY USA

来源：

PLANTA MEDICA | 2010年 / 76卷 / 15期

关键词：

Momordica charantia; Cucurbitaceae; cucurbitane-type triterpenoid; momordicoside U; OVIPOSITION DETERRENT; LIRIOMYZA-TRIFOLII; GLYCOSIDES; CONSTITUENTS; LEAFMINER; LEAVES; FRUITS;

D O I：

10.1055/s-0030-1249807

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3 beta,7 beta,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), momordicine I(3), momordicine II(4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-beta-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for insulin secretion activity in an in vitro insulin secretion assay and displayed moderate activity.

引用

页码：1758 / 1761

页数：4

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