Synthesis and antimicrobial activity of bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]methanes

A series of novel bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]methanes 6a-j have been prepared and their structures confirmed by IR, NMR. MS and elemental analyses. All the synthesized compounds have been tested for their antimicrobial activity against Gram-positive and Gram-negative bacteria, and fungi. Among the synthesized compounds, 6c, 6e, 6f and 6g are found to be the most active against Bacillus subtilis. Bacillus sphaericus, Staphylococcus aureus, Klebsiella aerogenes and Chromobacterium violaceum. Similarly, these compounds show potent,, antifungal effect against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes.