Two New Nimbolinin-Type Limonoids from the Fruits of Melia toosendan

被引：13

作者：

Zhang, Qiong ^{[1
]}

Zhang, Yong-Gang ^{[1
]}

Li, Qing-Shan ^{[1
]}

Min, Zhi-Da ^{[2
]}

机构：

[1] Shanxi Med Univ, Dept Pharmaceut Sci, Taiyuan 030001, Peoples R China

[2] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2016年 / 99卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Melia toosendan; Meliaceae; Limonoid; Nimbolinin; Cytotoxicity; TRITERPENOIDS; CHEMISTRY;

D O I：

10.1002/hlca.201500516

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new nimbolinin-type limonoids, 12-ethoxynimbolinins E and F (1 and 2, resp.), together with seven known analogues, 1-benzoyloxy-3-acetoxyl-7-hydroxy-12-ethoxynimbolinin (3), nimbolinin B (4), meliatoosenin L (5), 14,15-deoxy-11-oxohavanensin 3,12-diacetate (6), 12-hydroxymeliatoosenin (7), toosendansin A (8), and toosendansin C (9), were isolated from the fruits of Melia toosendan. The structures of these compounds were elucidated by spectroscopic analysis. All the compounds were evaluated for their cytotoxicity against five tumor cell lines.

引用

页码：462 / 465

页数：4