Two New Nimbolinin-Type Limonoids from the Fruits of Melia toosendan

被引：13

作者：

Zhang, Qiong ^{[1
]}

Zhang, Yong-Gang ^{[1
]}

Li, Qing-Shan ^{[1
]}

Min, Zhi-Da ^{[2
]}

机构：

[1] Shanxi Med Univ, Dept Pharmaceut Sci, Taiyuan 030001, Peoples R China

[2] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2016年 / 99卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Melia toosendan; Meliaceae; Limonoid; Nimbolinin; Cytotoxicity; TRITERPENOIDS; CHEMISTRY;

D O I：

10.1002/hlca.201500516

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new nimbolinin-type limonoids, 12-ethoxynimbolinins E and F (1 and 2, resp.), together with seven known analogues, 1-benzoyloxy-3-acetoxyl-7-hydroxy-12-ethoxynimbolinin (3), nimbolinin B (4), meliatoosenin L (5), 14,15-deoxy-11-oxohavanensin 3,12-diacetate (6), 12-hydroxymeliatoosenin (7), toosendansin A (8), and toosendansin C (9), were isolated from the fruits of Melia toosendan. The structures of these compounds were elucidated by spectroscopic analysis. All the compounds were evaluated for their cytotoxicity against five tumor cell lines.

引用

页码：462 / 465

页数：4

共 11 条

[1] [Anonymous], 1997, FLORA REPUBLICAE POP, V43, P102
[2] Triterpenoids with anti-tobacco mosaic virus activities from Melia Toosendan
Chen, Lin
Zhang, Jian-Xin
Wang, Bin
Mu, Shu-Zhen
Hao, Xiao-Jiang
[J]. FITOTERAPIA, 2014, 97 : 204 - 210
[3] Fang X, 2011, CURR ORG CHEM, V15, P1363
[4] NEW TETRANORTRITERPENOIDS FROM MELIA-AZEDARACH LINN (MELIACEAE)
KRAUS, W
BOKEL, M
[J]. CHEMISCHE BERICHTE-RECUEIL, 1981, 114 (01): : 267 - 275
[5] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS
MOSMANN, T
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) : 55 - 63
[6] Meliaceous Limonoids: Chemistry and Biological Activities
Tan, Qin-Gang
Luo, Xiao-Dong
[J]. CHEMICAL REVIEWS, 2011, 111 (11) : 7437 - 7522
[7] Khayanolides from African mahogany Khaya senegalensis (Meliaceae): A revision
Zhang, Huaping
Tan, Junjie
VanDerveer, Don
Wang, Xi
Wargovich, Michael J.
Chen, Feng
[J]. PHYTOCHEMISTRY, 2009, 70 (02) : 294 - 299
[8] Novel NGF-potentiating limonoids from the fruits of Melia toosendan
Zhang, Qiong
Li, Jian-Kuan
Ge, Rui
Liang, Jing-Yu
Li, Qing-Shan
Min, Zhi-Da
[J]. FITOTERAPIA, 2013, 90 : 192 - 198
[9] Limonoids from the fruits of Melia toosendan
Zhang, Yi
Tang, Chun-Ping
Ke, Chang-Qiang
Li, Xi-Qiang
Xie, Hua
Ye, Yang
[J]. PHYTOCHEMISTRY, 2012, 73 : 106 - 113
[10] Limonoids and Triterpenoids from the Stem Bark of Melia toosendan
Zhang, Yi
Tang, Chun-Ping
Ke, Chang-Qiang
Yao, Sheng
Ye, Yang
[J]. JOURNAL OF NATURAL PRODUCTS, 2010, 73 (04): : 664 - 668

← 1 2 →