First Survey of SNPs in TMEM154, TLR9, MYD88 and CCR5 Genes in Sheep Reared in Italy and Their Association with Resistance to SRLVs Infection

被引：14
作者：
Arcangeli, Chiara [1 ,2 ]
Lucarelli, Daniele [1 ]
Torricelli, Martina [1 ]
Sebastiani, Carla [1 ]
Ciullo, Marcella [1 ]
Pellegrini, Claudia [1 ]
Felici, Andrea [1 ]
Costarelli, Silva [1 ]
Giammarioli, Monica [1 ]
Feliziani, Francesco [1 ]
Passamonti, Fabrizio [2 ]
Biagetti, Massimo [1 ]
机构：
[1] Ist Zooprofilatt Sperimentale Umbria & Marche Tog, Via Salvemini 1, I-06126 Perugia, Italy
[2] Univ Perugia, Dipartimento Med Vet, Via San Costanzo 4, I-06126 Perugia, Italy
来源：
VIRUSES-BASEL | 2021年 / 13卷 / 07期
关键词：
small ruminant lentiviruses (SRLVs); transmembrane protein 154 (TMEM154); toll-like receptor 9 (TLR9); myeloid differentiation primary response 88 (MYD88); chemokine (C-C motif) receptor 5 (CCR5); genetic resistance; relative risk; SMALL RUMINANT LENTIVIRUSES; VIRUS-INFECTION; TRANSMISSION; CCR5-DELTA-32; DEFICIENCY; MUTATIONS; VARIANTS; GOATS;
D O I：
10.3390/v13071290
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Maedi-visna virus (MVV) and caprine arthritis encephalitis virus (CAEV), referred to as small ruminant lentiviruses (SRLVs), belong to the genus Lentivirus of the Retroviridae family. SRLVs infect both sheep and goats, causing significant economic losses and animal welfare damage. Recent findings suggest an association between serological status and allelic variants of different genes such as TMEM154, TLR9, MYD88 and CCR5. The aim of this work was to investigate the role of specific polymorphisms of these genes in SRLVs infection in some sheep flocks in Italy. In addition to those already known, novel variants in the TMEM154 (P7H, I74V, I105V) gene were detected in this study. The risk of infection was determined finding an association between the serological status and polymorphisms P7H, E35K, N70I, I74V, I105V of TMEM154, R447Q, A462S and G520R in TLR9 gene, H176H* and K190K* in MYD88 genes, while no statistical association was observed for the 4-bp deletion of the CCR5 gene. Since no vaccines or treatments have been developed, a genetically based approach could be an innovative strategy to prevent and to control SRLVs infection. Our findings are an important starting point in order to define the genetic resistance profile towards SRLVs infection.
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页数：12
相关论文
共 43 条
  • [1] CCR5Δ32 mutation and HIV infection: basis for curative HIV therapy
    Allers, Kristina
    Schneider, Thomas
    [J]. CURRENT OPINION IN VIROLOGY, 2015, 14 : 24 - 29
  • [2] Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock
    Alshanbari, F. A.
    Mousel, M. R.
    Reynolds, J. O.
    Herrmann-Hoesing, L. M.
    Highland, M. A.
    Lewis, G. S.
    White, S. N.
    [J]. ANIMAL GENETICS, 2014, 45 (04) : 565 - 571
  • [3] Altman D.G., 1991, Practical statistics for medical research
  • [4] [Anonymous], MEDCALC MANUAL EASY
  • [5] Small ruminant lentiviruses: Immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus
    Blacklaws, Barbara A.
    [J]. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2012, 35 (03) : 259 - 269
  • [6] SRLVs: A Genetic Continuum of Lentiviral Species in Sheep and Goats with Cumulative Evidence of Cross Species Transmission
    Caroline, Leroux
    Minardi, Cruz Juliano Cezar
    Jean-Francois, Mornex
    [J]. CURRENT HIV RESEARCH, 2010, 8 (01) : 94 - 100
  • [7] Small ruminant lentiviruses in goats in southern Italy: Serological evidence, risk factors and implementation of control programs
    Cirone, Francesco
    Maggiolino, Aristide
    Cirilli, Margie
    Sposato, Alessio
    De Palo, Pasquale
    Ciappetta, Giacinto
    Pratelli, Annamaria
    [J]. VETERINARY MICROBIOLOGY, 2019, 228 : 143 - 146
  • [8] Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4Δ53
    Clawson, Michael L.
    Redden, Reid
    Schuller, Gennie
    Heaton, Michael P.
    Workman, Aspen
    Chitko-McKown, Carol G.
    Smith, Timothy Pl
    Leymaster, Kreg A.
    [J]. VETERINARY RESEARCH, 2015, 46
  • [9] A single nucleotide variant in the promoter region of the CCR5 gene increases susceptibility to arthritis encephalitis virus in goats
    Colussi, Silvia
    Desiato, Rosanna
    Beltramo, Chiara
    Peletto, Simone
    Modesto, Paola
    Maniaci, Maria Grazia
    Campia, Valentina
    Quasso, Antonio
    Rosati, Sergio
    Bertolotti, Luigi
    Ru, Giuseppe
    Acutis, Pier Luigi
    [J]. BMC VETERINARY RESEARCH, 2019, 15 (1)
  • [10] Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus
    Dawson, TC
    Beck, MA
    Kuziel, WA
    Henderson, F
    Maeda, N
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (06) : 1951 - 1959
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