First Survey of SNPs in TMEM154, TLR9, MYD88 and CCR5 Genes in Sheep Reared in Italy and Their Association with Resistance to SRLVs Infection

被引：14

作者：

Arcangeli, Chiara ^{[1
,2
]}

Lucarelli, Daniele ^{[1
]}

Torricelli, Martina ^{[1
]}

Sebastiani, Carla ^{[1
]}

Ciullo, Marcella ^{[1
]}

Pellegrini, Claudia ^{[1
]}

Felici, Andrea ^{[1
]}

Costarelli, Silva ^{[1
]}

Giammarioli, Monica ^{[1
]}

Feliziani, Francesco ^{[1
]}

Passamonti, Fabrizio ^{[2
]}

Biagetti, Massimo ^{[1
]}

机构：

[1] Ist Zooprofilatt Sperimentale Umbria & Marche Tog, Via Salvemini 1, I-06126 Perugia, Italy

[2] Univ Perugia, Dipartimento Med Vet, Via San Costanzo 4, I-06126 Perugia, Italy

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 07期

关键词：

small ruminant lentiviruses (SRLVs); transmembrane protein 154 (TMEM154); toll-like receptor 9 (TLR9); myeloid differentiation primary response 88 (MYD88); chemokine (C-C motif) receptor 5 (CCR5); genetic resistance; relative risk; SMALL RUMINANT LENTIVIRUSES; VIRUS-INFECTION; TRANSMISSION; CCR5-DELTA-32; DEFICIENCY; MUTATIONS; VARIANTS; GOATS;

D O I：

10.3390/v13071290

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Maedi-visna virus (MVV) and caprine arthritis encephalitis virus (CAEV), referred to as small ruminant lentiviruses (SRLVs), belong to the genus Lentivirus of the Retroviridae family. SRLVs infect both sheep and goats, causing significant economic losses and animal welfare damage. Recent findings suggest an association between serological status and allelic variants of different genes such as TMEM154, TLR9, MYD88 and CCR5. The aim of this work was to investigate the role of specific polymorphisms of these genes in SRLVs infection in some sheep flocks in Italy. In addition to those already known, novel variants in the TMEM154 (P7H, I74V, I105V) gene were detected in this study. The risk of infection was determined finding an association between the serological status and polymorphisms P7H, E35K, N70I, I74V, I105V of TMEM154, R447Q, A462S and G520R in TLR9 gene, H176H* and K190K* in MYD88 genes, while no statistical association was observed for the 4-bp deletion of the CCR5 gene. Since no vaccines or treatments have been developed, a genetically based approach could be an innovative strategy to prevent and to control SRLVs infection. Our findings are an important starting point in order to define the genetic resistance profile towards SRLVs infection.

引用

页数：12

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