Chitin synthesis and fungal pathogenesis

被引：353

作者：

Lenardon, Megan D. ^{[1
]}

Munro, Carol A. ^{[1
]}

Gow, Neil A. R. ^{[1
]}

机构：

[1] Univ Aberdeen, Aberdeen Fungal Grp, Sch Med Sci, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

CURRENT OPINION IN MICROBIOLOGY | 2010年 / 13卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

MOTOR-LIKE DOMAIN; CANDIDA-ALBICANS; CELL-WALL; SACCHAROMYCES-CEREVISIAE; CLASS-V; POLARIZED GROWTH; SYNTHASE; YEAST; ACTIVATION; RECOGNITION;

D O I：

10.1016/j.mib.2010.05.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chitin is an essential part of the carbohydrate skeleton of the fungal cell wall and is a molecule that is not represented in humans and other vertebrates. Complex regulatory mechanisms enable chitin to be positioned at specific sites throughout the cell cycle to maintain the overall strength of the wall and enable rapid, life-saving modifications to be made under cell wall stress conditions. Chitin has also recently emerged as a significant player in the activation and attenuation of immune responses to fungi and other chitin-containing parasites. This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis.

引用

页码：416 / 423

页数：8

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