Physico-chemical stability evaluation of a non-ionic cream (Base) included on national formulary

Physico-Chemical Stability Evaluation of a Non-Ionic Cream (Base) Included on National Formulary. The National Formulary (NF) is the Brazilian official code where are contained official pharmaceutical formulations in order to standardize related drugs and cosmetics, assuring their quality. Among the indexed dermatological bases, non-ionic cream stands out because of its ease to incorpore pharmaceutical and cosmetic active principles, widely being used as vehicle in several formulations. Considering that listed formulations must have guaranteed stability, the present study purposed to assess stability and physico-chemical characteristics of this base. This study started with the cream preparation according to NF methodology. Samples were evaluated about organoleptic properties, pH variation, viscosity, spreadability and distribution of particle sizes during twelve weeks. In this study, it was noticed that the product showed a good pseudoplastic behavior. Except for the viscosity that was altered compared to starting and ending values and it brought about significative changes on spreadability values, the base showed good stability and seemed to be an appropriate vehicle for drug incorporations.