Efficacy and long-term tuning parameters of vagus nerve stimulation in long-term treated depressive patients

被引：13
作者：
Mueller, Helge H. O. [1 ,2 ]
Luecke, Caroline [2 ]
Moeller, Sebastian [2 ]
Philipsen, Alexandra [2 ]
Sperling, Wolfgang [1 ]
机构：
[1] Friedrich Alexander Univ, Univ Hosp Erlangen Nuremberg, Dept Psychiat & Psychotherapy, Erlangen, Germany
[2] Carl von Ossietzky Univ Oldenburg, Sch Med & Hlth Sci, Psychiat & Psychotherapy Univ Hosp, Karl Jaspers Klin, Med Campus,Hermann Ehlers Str 7, D-26160 Bad Zwischenahn, Germany
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2017年 / 44卷
关键词：
Vagus nerve stimulation; Depression; Neurostimulation; TREATMENT-RESISTANT DEPRESSION; THERAPY; METAANALYSIS; VNS;
D O I：
10.1016/j.jocn.2017.06.020
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Vagus nerve stimulation (VNS) is a promising neurostimulation tool for the treatment of treatment resistant depression. Here, we report the effects of positive remission rates and tuning parameters in a group of 18 (6 female, 12 male, mean age 54) long-term treated patients. Treatment varied between 3 and 200 months (mean 104.9 months). Mean stimulation intensity was 1.46 mA, ranging from 0.5 to 2.0 mA and high-frequency stimulation of 20-25 Hz (mean 23.61 Hz). The remission rates in our study population clearly indicate ongoing positive effects of VNS and highlight stimulation tunings between 0.5 and 2.0 mA and 20-25 Hz as best dosage for achieving remittance in long-term treatment of VNS. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：340 / 341
页数：2
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