The Bidirectional Relationship between Vision and Cognition A Systematic Review and Meta-analysis

被引：59

作者：

Tai Anh Vu ^{[1
]}

Fenwick, Eva K. ^{[1
,2
]}

Gan, Alfred T. L. ^{[2
]}

Man, Ryan E. K. ^{[1
,2
]}

Tan, Benjamin K. J. ^{[3
]}

Gupta, Preeti ^{[2
]}

Ho, Kam Chun ^{[2
,4
,5
]}

Reyes-Ortiz, Carlos A. ^{[6
]}

Trompet, Stella ^{[7
]}

Gussekloo, Jacobijn ^{[7
]}

O'Brien, Joan M. ^{[8
]}

Mueller-Schotte, Sigrid ^{[9
,10
]}

Wong, Tien Yin ^{[1
,2
]}

Tham, Yih Chung ^{[2
]}

Cheng, Ching-Yu ^{[1
,2
]}

Lee, Allen T. C. ^{[11
]}

Rait, Greta ^{[12
]}

Swenor, Bonnielin K. ^{[13
]}

Varadaraj, Varshini ^{[13
]}

Brenowitz, Willa D. ^{[14
]}

Medeiros, Felipe A. ^{[15
]}

Nael, Virginie ^{[16
]}

Narasimhalu, Kaavya ^{[1
,17
]}

Chen, Christopher L. H. ^{[18
]}

Lamoureux, Ecosse L. ^{[1
,2
,19
]}

机构：

[1] Duke NUS Med Sch, Singapore, Singapore

[2] Singapore Natl Eye Ctr, Singapore Eye Res Inst, 20 Coll Rd,Discovery Tower Level 6, Singapore 169856, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[4] Univ New South Wales, Sch Optometry & Visual Sci, Sydney, NSW, Australia

[5] George Inst Global Hlth, Injury Div, Sydney, NSW, Australia

[6] Agr & Mech Univ, Coll Pharm & Pharmaceut Sci Ences, Inst Publ Hlth, Tallahassee, FL USA

[7] Leiden Univ, Med Ctr, Leiden, Netherlands

[8] Univ Penn, Scheie Eye Inst, Philadelphia, PA 19104 USA

[9] Univ Med Ctr Utrecht, Utrecht, Netherlands

[10] Univ Appl Sci Utrecht, Utrecht, Netherlands

[11] Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Hong Kong, Peoples R China

[12] UCL, Dept Primary Care & Populat Hlth, London, England

[13] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA

[14] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[15] Duke Univ, Ctr Eye, Dept Ophthalmol, Durham, NC 27710 USA

[16] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Bordeaux, France

[17] Natl Neurosci Inst, Singapore Gen Hosp Campus, Singapore, Singapore

[18] Natl Univ Singapore, Memory Aging & Cognit Ctr, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore

[19] Univ Melbourne, Dept Ophthalmol, Melbourne, Vic, Australia

来源：

OPHTHALMOLOGY | 2021年 / 128卷 / 07期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Bidirectional; Cognitive impairment; Dementia; Visual acuity; Visual impairment; QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; VISUAL IMPAIRMENT; OLDER-ADULTS; SENSORY IMPAIRMENT; RISK-FACTORS; AGE; ASSOCIATION; DEMENTIA; DECLINE;

D O I：

10.1016/j.ophtha.2020.12.010

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Topic: Visual impairment (VI) and cognitive impairment (CIM) are prevalent age-related conditions that impose substantial burden on the society. Findings on the hypothesized bidirectional association of VI and CIM remains equivocal. Hence, we conducted a systematic review and meta-analysis to examine this bidirectional relationship. Methods: PubMed, Embase, and Cochrane Central registers were searched systematically for observational studies, published from inception until April 6, 2020, in adults 40 years of age or older reporting objectively measured VI and CIM assessment using clinically validated cognitive screening tests or diagnostic evaluation. Meta-analyses on cross-sectional and longitudinal associations between VI and CIM outcomes (any CIM assessed using screening tests and clinically diagnosed dementia) were examined. Random effect models were used to generate pooled odds ratios (ORs) and 95% confidence intervals (CIs). We also examined study quality, publication bias, and heterogeneity. Results: Forty studies were included (n=47 913 570). Meta-analyses confirmed that persons with VI were more likely to have CIM, with significantly higher odds of: (1) any CIM (cross-sectional: OR, 2.38 [95% CI, 1.84-3.07]; longitudinal: OR, 1.66 [95% CI, 1.46-1.89]) and (2) clinically diagnosed dementia (cross-sectional: OR, 2.43 [95% CI, 1.48-4.01]; longitudinal: OR, 2.09 [95% CI, 1.37-3.21]) compared with persons without VI. Significant heterogeneity was explained partially by differences in age, sex, and follow-up duration. Also, some evidence suggested that individuals with CIM, relative to cognitively intact persons, were more likely to have VI, with most articles (8/9 [89%]) reporting significantly positive associations; however, meta-analyses on this association could not be conducted because of insufficient data. Discussion: Overall, our work suggests that VI is a risk factor of CIM, although further work is needed to confirm the association of CIM as a risk factor for VI. Strategies for early detection and management of both conditions in older peoplemay minimize individual clinical and public health consequences. (C) 2020 by the American Academy of Ophthalmology

引用

页码：981 / 992

页数：12

共 98 条

[1] A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia [J].