Guiding Effect of Serum Procalcitonin (PCT) on the Antibiotic Application to Patients with Sepsis

被引：16
作者：
Liu, Yu [1 ]
Yang, Weize [1 ]
Wei, Jie [1 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Emergency, Wuhan, Hubei, Peoples R China
来源：
IRANIAN JOURNAL OF PUBLIC HEALTH | 2017年 / 46卷 / 11期
关键词：
Sepsis; Serum; Procalcitonin; Antibiotic; INTENSIVE-CARE; PNEUMONIA; DIAGNOSIS; CHILDREN; DEATH;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background: This study aimed to investigate the guiding effect of serum procalcitonin (PCT) on the antibiotic application to patients with sepsis. Methods: Ninety-eight patients with sepsis treated in Renmin Hospital of Wuhan University, China from 2015-2017 were enrolled. They were divided into two equal groups of control group and the observation group. Patients in the observation group received the antibiotic therapy guided by PCT while patients in the control group received the regular antibiotic therapy. The conventional indexes, prognosis and clinical effects of the two groups were compared. Results: There were no statistical significance in the differences of the Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores C-reactive protein (CRP) and white blood cell count (WBC) levels between the two groups. The duration of the antibiotic application to patients in the observation group was (7.74 +/- 0.61) d which was (10.22 +/- 0.78) d shorter than that to patients in the control group. The difference was statistically significant (P<0.05). The Intensive Care Unit (ICU) stay time and the hospital stays of patients in the observation group were shorter than those of patients in the control group. The difference had statistical significance (P<0.05). The difference in 30-dayrecurrence rate and 30 day-mortality of the patients in the two groups had no statistical significance. There was statistically significant difference in the comparison of the clinical effects between the two groups. Conclusion: Guiding effects of the serum PCT on the application of antibiotics to patients with sepsis shorten the usage time of the antibiotics, ICU stay time and hospital stays.
引用
收藏
页码：1535 / 1539
页数：5
相关论文
共 12 条
[1]   Diagnostic and prognostic role of procalcitonin (PCT) and MR-pro-Adrenomedullin (MR-proADM) in bacterial infections [J].
Angeletti, Silvia ;
Spoto, Silvia ;
Fogolari, Marta ;
Cortigiani, Marco ;
Fioravanti, Marta ;
de Florio, Lucia ;
Curcio, Brunella ;
Cavalieri, Danilo ;
Costantino, Sebastiano ;
Dicuonzo, Giordano .
APMIS, 2015, 123 (09) :740-748
[2]   Effect of Introducing Procalcitonin on Antimicrobial Therapy Duration in Patients With Sepsis and/or Pneumonia in the Intensive Care Unit [J].
Bishop, Bryan M. ;
Bon, John J. ;
Trienski, Tamara L. ;
Pasquale, Timothy R. ;
Martin, Bradley R. ;
File, Thomas M., Jr. .
ANNALS OF PHARMACOTHERAPY, 2014, 48 (05) :577-583
[3]   Lactate Measurements in Sepsis-Induced Tissue Hypoperfusion: Results From the Surviving Sepsis Campaign Database [J].
Casserly, Brian ;
Phillips, Gary S. ;
Schorr, Christa ;
Dellinger, R. Phillip ;
Townsend, Sean R. ;
Osborn, Tiffany M. ;
Reinhart, Konrad ;
Selvakumar, Narendran ;
Levy, Mitchell M. .
CRITICAL CARE MEDICINE, 2015, 43 (03) :567-573
[4]   Timing of Death in Children Referred for Intensive Care With Severe Sepsis: Implications for Interventional Studies [J].
Cvetkovic, Mirjana ;
Lutman, Daniel ;
Ramnarayan, Padmanabhan ;
Pathan, Nazima ;
Inwald, David P. ;
Peters, Mark J. .
PEDIATRIC CRITICAL CARE MEDICINE, 2015, 16 (05) :410-417
[5]   C-Terminal Agrin Fragment (CAF) Reflects Renal Function in Patients Suffering from Severe Sepsis or Septic Shock [J].
Drey, Michael ;
Behnes, Michael ;
Kob, Robert ;
Lepiorz, Dominic ;
Hettwer, Stefan ;
Bollheimer, Cornelius ;
Sieber, Cornel C. ;
Bertsch, Thomas ;
Hoffmann, Ursula .
CLINICAL LABORATORY, 2015, 61 (1-2) :69-76
[6]   Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis: A multicenter prospective study [J].
Endo, Shigeatsu ;
Suzuki, Yasushi ;
Takahashi, Gaku ;
Shozushima, Tatsuyori ;
Ishikura, Hiroyasu ;
Murai, Akira ;
Nishida, Takeshi ;
Irie, Yuhei ;
Miura, Masanao ;
Iguchi, Hironobu ;
Fukui, Yasuo ;
Tanaka, Kimiaki ;
Nojima, Tsuyoshi ;
Okamura, Yoshikazu .
JOURNAL OF INFECTION AND CHEMOTHERAPY, 2014, 20 (1-2) :30-34
[7]   A national quality improvement initiative for reducing harm and death from sepsis in Wales [J].
Hancock, Chris .
INTENSIVE AND CRITICAL CARE NURSING, 2015, 31 (02) :100-105
[8]   Randomized, Placebo-Controlled Trial of Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis: The Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis Trial [J].
Janz, David R. ;
Bastarache, Julie A. ;
Rice, Todd W. ;
Bernard, Gordoi R. ;
Warren, Melissa A. ;
Wickersham, Nancy ;
Sills, Gillian ;
Oates, John A. ;
Roberts, L. Jackson, II ;
Ware, Lorraine B. .
CRITICAL CARE MEDICINE, 2015, 43 (03) :534-541
[9]   Procalcitonin and interleukin 6 for predicting blood culture positivity in sepsis [J].
Naffaa, Mohammad ;
Makhoul, Badira F. ;
Tobia, Amjad ;
Kaplan, Marielle ;
Aronson, Doron ;
Azzam, Zaher S. ;
Saliba, Walid .
AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2014, 32 (05) :448-451
[10]   Total internal reflection (TIRF)-based quantification of procalcitonin for sepsis diagnosis - A point-of-care testing application [J].
Rascher, Daniela ;
Geerlof, Arie ;
Kremmer, Elisabeth ;
Kraemer, Petra ;
Michael, Schmid ;
Hartmann, Anton ;
Rieger, Martin .
BIOSENSORS & BIOELECTRONICS, 2014, 59 :251-258
12