Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans

被引：10

作者：

Scherr, Nicole ^{[1
,2
]}

Pluschke, Gerd ^{[1
,2
]}

Panda, Manoranjan ^{[3
]}

机构：

[1] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] AstraZeneca India Pvt Ltd, iMED Infect, Dept Chem, Bangalore, Karnataka, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 05期

关键词：

IN-VITRO ACTIVITY; SMALL-MOLECULE; II TOPOISOMERASE; CAUSATIVE AGENT; INHIBITORS; COMBINATION; INFECTION; DIARYLTHIAZOLE; STREPTOMYCIN; MYCOLACTONE;

D O I：

10.1128/AAC.02658-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against Mycobacterium ulcerans, the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against M. ulcerans, five compounds showed high activity (90% inhibitory concentration [IC90], <= 1 mu M), making screening of focused antitubercular libraries a good starting point for lead generation against M. ulcerans.

引用

页码：3132 / 3137

页数：6

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