Asymmetric cell division: recent developments and their implications for tumour biology

被引：438

作者：

Knoblich, Juergen A. ^{[1
]}

机构：

[1] Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 12期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

REGULATES SPINDLE ORIENTATION; NEUROBLAST SELF-RENEWAL; ACUTE MYELOID-LEUKEMIA; NEURAL STEM-CELLS; C-ELEGANS; CORTICAL POLARITY; PAR-COMPLEX; NEURONAL DIFFERENTIATION; BLASTOMERE IDENTITY; SUPPRESSOR PROTEIN;

D O I：

10.1038/nrm3010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ability of cells to divide asymmetrically is essential for generating diverse cell types during development. The past 10 years have seen tremendous progress in our understanding of this important biological process. We have learned that localized phosphorylation events are responsible for the asymmetric segregation of cell fate determinants in mitosis and that centrosomes and microtubules play important parts in this process. The relevance of asymmetric cell division for stem cell biology has added a new dimension to the field, and exciting connections between asymmetric cell division and tumorigenesis have begun to emerge.

引用

页码：849 / 860

页数：12

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