Plasma interleukin-2 levels and thyroid function in elderly patients with nonthyroidal illness

被引：5

作者：

Allegra, A ^{[1
]}

Corica, F ^{[1
]}

Buemi, M ^{[1
]}

Corsonello, A ^{[1
]}

Rubino, F ^{[1
]}

Addamo, FR ^{[1
]}

Bonanzinga, S ^{[1
]}

Mauro, VN ^{[1
]}

Caruso, D ^{[1
]}

机构：

[1] Univ Messina, Sch Med, Policlin Univ,Div Internal Med & Metab Dis, Dept Internal Med, I-98124 Messina, Italy

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1998年 / 26卷 / 03期

关键词：

low T-3 syndrome; interleukin-2; aging; nonthyroidal illness; thyroid;

D O I：

10.1016/S0167-4943(98)00010-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

To determine whether interleukin-2 (IL-2) plasma concentrations are modified in patients with nonthyroidal illness (NTI) and thyroid function alterations, we measured plasma concentrations of T-3, T-4, free T-3 (FT3), free T-4 (FT4), TSH, and IL-2 in 34 elderly NTI patients and in 25 age- and sex-matched healthy controls. IL-2 was detectable in II of the 34 patients. Patients with detectable IL-2 plasma levels had significantly lower plasma T-3 and FT3 concentrations when compared to those with undetectable IL-2. Moreover, IL-2 plasma levels were positively correlated to reverse T-3 (rT(3)), (r(s)=0.67, P<0.05), and negatively to FT3 concentrations (r(s) = -0.64, P<0.05). These observations suggest that some of the alterations in thyroid hormone levels seen in NTI are associated with elevated plasma concentrations of IL-2. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：275 / 282

页数：8

共 23 条

[1] RELATIONSHIP OF THE INCREASED SERUM INTERLEUKIN-6 CONCENTRATION TO CHANGES OF THYROID-FUNCTION IN NONTHYROIDAL ILLNESS [J].