Palladium-catalyzed one-pot Catellani reaction: An efficient synthesis of α-alkynyl aromatic ketones via ortho acylation and ipso alkynylation

被引：7

作者：

Yu, Shao-Peng ^{[1
]}

Zhong, Yue ^{[1
]}

Gu, Ting ^{[1
]}

Wu, Wen-Yu ^{[1
]}

Fan, Tian Yuan ^{[1
]}

Li, Nian-Guang ^{[1
]}

Shi, Zhi-Hao ^{[2
]}

Tang, Yu-Ping ^{[1
,3
,4
]}

Duan, Jin-Ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Organ Chem, Nanjing 211198, Jiangsu, Peoples R China

[3] Shaanxi Univ Chinese Med, Coll Pharm, Xian 712046, Shaanxi, Peoples R China

[4] Shaanxi Univ Chinese Med, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Xian 712046, Shaanxi, Peoples R China

来源：

TETRAHEDRON | 2018年 / 74卷 / 40期

关键词：

Catellani reaction; Acylation; Alkynylation; 2-Alkynyl aromatic ketones; Palladium-catalyzed; C-H FUNCTIONALIZATION; ARYL IODIDES; REGIOSPECIFIC SYNTHESIS; ALKYLATION; PD/NORBORNENE; ACTIVATION; ANNULATION; AMINATION;

D O I：

10.1016/j.tet.2018.08.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed and norbornene-mediated Catellani reaction was developed through ortho-acylation and ipso-alkynylation for the aryl iodides. Acyl chlorides were used as acylation reagents and phenylpropiolic acids were used as termination reagents respectively in this transformation. As a result, the reactivity of these three different compounds matched well and this unreported combination could be used extensively. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：5942 / 5949

页数：8

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