Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair

被引：217
|
作者：
Stenudd, Moa [1 ]
Sabelstroem, Hanna [1 ]
Frisen, Jonas [1 ]
机构：
[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
来源：
JAMA NEUROLOGY | 2015年 / 72卷 / 02期
基金：
瑞典研究理事会;
关键词：
CNS; TISSUE; ORIGIN; DAMAGE;
D O I：
10.1001/jamaneurol.2014.2927
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Spinal cord injury is followed by glial scar formation, which has positive and negative effects on recovery from the lesion. More than half of the astrocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cord. We recently demonstrated that the neural stem cell-derived scar component has several beneficial functions, including restricting tissue damage and neural loss after spinal cord injury. This finding identifies endogenous neural stem cells as a potential therapeutic target for treatment of spinal cord injury.
引用
收藏
页码：235 / 237
页数：3
相关论文
共 50 条
  • [21] Endogenous neural progenitor cells in the repair of the injured spinal cord
    Mao, Yilin
    Tara Nguyen
    Sutherland, Theresa
    Gorrie, Catherine Anne
    NEURAL REGENERATION RESEARCH, 2016, 11 (07) : 1075 - 1076
  • [22] Neural stem cell transplantation in the repair of spinal cord injury
    Iannotti, C
    Lü, XB
    Lu, PH
    Xu, XM
    PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, 2001, 11 (07) : 490 - +
  • [23] Neural stem cell transplantation in the repair of spinal cord injury
    Christopher IANNOTTI
    吕晓斌
    陆佩华
    徐晓明
    Progress in Natural Science, 2001, (07) : 12 - 24+83-84
  • [24] Revisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair
    Wen, Runlin
    Long, Ge
    He, Xinghui
    Zhang, Kai
    Ma, Wanrong
    Shen, Yeyu
    Xiao, Zhifeng
    Zhao, Yannan
    Liu, Dingyang
    Dai, Jianwu
    Li, Xing
    THERANOSTICS, 2025, 15 (04): : 1552 - 1569
  • [25] Transplantation of adult neural stem cells for the repair of compressive spinal cord injury in rat
    Karimi-Abdolrezaee, S
    Eftekharpour, E
    Wang, J
    Morshead, C
    Fehlings, MG
    JOURNAL OF NEUROTRAUMA, 2004, 21 (09) : 1332 - 1332
  • [26] Repair of spinal cord injury by neural stem cells modified with BDNF gene in rats
    Wei LI~1
    ~2 Department of Histology and Embryology
    Neuroscience Bulletin, 2006, (01) : 34 - 40
  • [27] Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair
    Chen, Zhenni
    Zhang, Haimin
    Fan, Caixia
    Zhuang, Yan
    Yang, Wen
    Chen, Yanyan
    Shen, He
    Xiao, Zhifeng
    Zhao, Yannan
    Li, Xiaoran
    Dai, Jianwu
    ACS NANO, 2022, 16 (02) : 1986 - 1998
  • [28] Neural stem cells in models of spinal cord injury
    Tuszynski, Mark H.
    Wang, Yaozhi
    Graham, Lori
    McHale, Karla
    Gao, Mingyong
    Wu, Di
    Brock, John
    Blesch, Armin
    Rosenzweig, Ephron S.
    Havton, Leif A.
    Zheng, Binhai
    Conner, James M.
    Marsala, Martin
    Lu, Paul
    EXPERIMENTAL NEUROLOGY, 2014, 261 : 494 - 500
  • [29] Endogenous neural stem cell responses to stroke and spinal cord injury
    Gregoire, Catherine-Alexandra
    Goldenstein, Brianna L.
    Floriddia, Elisa M.
    Barnabe-Heider, Fanie
    Fernandes, Karl J. L.
    GLIA, 2015, 63 (08) : 1469 - 1482
  • [30] Deciphering the role of endogenous neural stem/progenitor cells in experimental spinal cord injury to identify new therapeutic targets
    Tomasso, Antonio
    Cusimano, Melania
    Brambilla, Elena
    Martino, Gianvito
    JOURNAL OF NEUROIMMUNOLOGY, 2014, 275 (1-2) : 194 - 195
12345