Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair

被引：217
|
作者：
Stenudd, Moa [1 ]
Sabelstroem, Hanna [1 ]
Frisen, Jonas [1 ]
机构：
[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
来源：
JAMA NEUROLOGY | 2015年 / 72卷 / 02期
基金：
瑞典研究理事会;
关键词：
CNS; TISSUE; ORIGIN; DAMAGE;
D O I：
10.1001/jamaneurol.2014.2927
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Spinal cord injury is followed by glial scar formation, which has positive and negative effects on recovery from the lesion. More than half of the astrocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cord. We recently demonstrated that the neural stem cell-derived scar component has several beneficial functions, including restricting tissue damage and neural loss after spinal cord injury. This finding identifies endogenous neural stem cells as a potential therapeutic target for treatment of spinal cord injury.
引用
收藏
页码：235 / 237
页数：3
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