Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair

被引：235

作者：

Stenudd, Moa ^{[1
]}

Sabelstroem, Hanna ^{[1
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

来源：

JAMA NEUROLOGY | 2015年 / 72卷 / 02期

基金：

瑞典研究理事会;

关键词：

CNS; TISSUE; ORIGIN; DAMAGE;

D O I：

10.1001/jamaneurol.2014.2927

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spinal cord injury is followed by glial scar formation, which has positive and negative effects on recovery from the lesion. More than half of the astrocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cord. We recently demonstrated that the neural stem cell-derived scar component has several beneficial functions, including restricting tissue damage and neural loss after spinal cord injury. This finding identifies endogenous neural stem cells as a potential therapeutic target for treatment of spinal cord injury.

引用

页码：235 / 237

页数：3

共 10 条

[1] The Adult Macaque Spinal Cord Central Canal Zone Contains Proliferative Cells and Closely Resembles the Human [J].

Alfaro-Cervello, Clara ;

Cebrian-Silla, Arantxa ;

Soriano-Navarro, Mario ;

Garcia-Tarraga, Patricia ;

Matias-Guiu, Jorge ;

Gomez-Pinedo, Ulises ;

Molina Aguilar, Pilar ;

Alvarez-Buylla, Arturo ;

Luquin, Maria-Rosario ;

Manuel Garcia-Verdugo, Jose .

JOURNAL OF COMPARATIVE NEUROLOGY, 2014, 522 (08) :1800-1817

[2] Origin of New Glial Cells in Intact and Injured Adult Spinal Cord [J].

Barnabe-Heider, Fanie ;

Goritz, Christian ;

Sabelstrom, Hanna ;

Takebayashi, Hirohide ;

Pfrieger, Frank W. ;

Meletis, Konstantinos ;

Frisen, Jonas .

CELL STEM CELL, 2010, 7 (04) :470-482

[3] Reactive Gliosis and the Multicellular Response to CNS Damage and Disease [J].

Burda, Joshua E. ;

Sofroniew, Michael V. .

NEURON, 2014, 81 (02) :229-248

[4] Remyelination in the CNS: from biology to therapy [J].

Franklin, Robin J. M. ;

ffrench-Constant, Charles .

NATURE REVIEWS NEUROSCIENCE, 2008, 9 (11) :839-855

[5] Neural Stem Cells: Generating and Regenerating the Brain [J].

Gage, Fred H. ;

Temple, Sally .

NEURON, 2013, 80 (03) :588-601

[6] A Pericyte Origin of Spinal Cord Scar Tissue [J].

Goritz, Christian ;

Dias, David O. ;

Tomilin, Nikolay ;

Barbacid, Mariano ;

Shupliakov, Oleg ;

Frisen, Jonas .

SCIENCE, 2011, 333 (6039) :238-242

[7] Neural stem cells in the adult spinal cord [J].

Sabelstrom, Hanna ;

Stenudd, Moa ;

Frisen, Jonas .

EXPERIMENTAL NEUROLOGY, 2014, 260 :44-49

[8] Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice [J].

Sabelstrom, Hanna ;

Stenudd, Moa ;

Reu, Pedro ;

Dias, David O. ;

Elfineh, Marta ;

Zdunek, Sofia ;

Damberg, Peter ;

Goritz, Christian ;

Frisen, Jonas .

SCIENCE, 2013, 342 (6158) :637-640

[9] From basics to clinical: A comprehensive review on spinal cord injury [J].

Silva, Nuno A. ;

Sousa, Nuno ;

Reis, Rui L. ;

Salgado, Antonio J. .

PROGRESS IN NEUROBIOLOGY, 2014, 114 :25-57

[10]

Weiss S, 1996, J NEUROSCI, V16, P7599

← 1 →