Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair

被引：219
作者：
Stenudd, Moa [1 ]
Sabelstroem, Hanna [1 ]
Frisen, Jonas [1 ]
机构：
[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
来源：
JAMA NEUROLOGY | 2015年 / 72卷 / 02期
基金：
瑞典研究理事会;
关键词：
CNS; TISSUE; ORIGIN; DAMAGE;
D O I：
10.1001/jamaneurol.2014.2927
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Spinal cord injury is followed by glial scar formation, which has positive and negative effects on recovery from the lesion. More than half of the astrocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cord. We recently demonstrated that the neural stem cell-derived scar component has several beneficial functions, including restricting tissue damage and neural loss after spinal cord injury. This finding identifies endogenous neural stem cells as a potential therapeutic target for treatment of spinal cord injury.
引用
收藏
页码：235 / 237
页数：3
相关论文
共 10 条
  • [1] The Adult Macaque Spinal Cord Central Canal Zone Contains Proliferative Cells and Closely Resembles the Human
    Alfaro-Cervello, Clara
    Cebrian-Silla, Arantxa
    Soriano-Navarro, Mario
    Garcia-Tarraga, Patricia
    Matias-Guiu, Jorge
    Gomez-Pinedo, Ulises
    Molina Aguilar, Pilar
    Alvarez-Buylla, Arturo
    Luquin, Maria-Rosario
    Manuel Garcia-Verdugo, Jose
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2014, 522 (08) : 1800 - 1817
  • [2] Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
    Barnabe-Heider, Fanie
    Goritz, Christian
    Sabelstrom, Hanna
    Takebayashi, Hirohide
    Pfrieger, Frank W.
    Meletis, Konstantinos
    Frisen, Jonas
    [J]. CELL STEM CELL, 2010, 7 (04) : 470 - 482
  • [3] Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
    Burda, Joshua E.
    Sofroniew, Michael V.
    [J]. NEURON, 2014, 81 (02) : 229 - 248
  • [4] Remyelination in the CNS: from biology to therapy
    Franklin, Robin J. M.
    ffrench-Constant, Charles
    [J]. NATURE REVIEWS NEUROSCIENCE, 2008, 9 (11) : 839 - 855
  • [5] Neural Stem Cells: Generating and Regenerating the Brain
    Gage, Fred H.
    Temple, Sally
    [J]. NEURON, 2013, 80 (03) : 588 - 601
  • [6] A Pericyte Origin of Spinal Cord Scar Tissue
    Goritz, Christian
    Dias, David O.
    Tomilin, Nikolay
    Barbacid, Mariano
    Shupliakov, Oleg
    Frisen, Jonas
    [J]. SCIENCE, 2011, 333 (6039) : 238 - 242
  • [7] Neural stem cells in the adult spinal cord
    Sabelstrom, Hanna
    Stenudd, Moa
    Frisen, Jonas
    [J]. EXPERIMENTAL NEUROLOGY, 2014, 260 : 44 - 49
  • [8] Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
    Sabelstrom, Hanna
    Stenudd, Moa
    Reu, Pedro
    Dias, David O.
    Elfineh, Marta
    Zdunek, Sofia
    Damberg, Peter
    Goritz, Christian
    Frisen, Jonas
    [J]. SCIENCE, 2013, 342 (6158) : 637 - 640
  • [9] From basics to clinical: A comprehensive review on spinal cord injury
    Silva, Nuno A.
    Sousa, Nuno
    Reis, Rui L.
    Salgado, Antonio J.
    [J]. PROGRESS IN NEUROBIOLOGY, 2014, 114 : 25 - 57
  • [10] Weiss S, 1996, J NEUROSCI, V16, P7599
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