APOE genotype and verbal memory recovery during and after emergence from post-traumatic amnesia

被引:21
作者
Noe, E. [1 ]
Ferri, J. [1 ]
Colomer, C. [1 ]
Moliner, B. [1 ]
Chirivella, J. [1 ]
机构
[1] Hosp Valencia Mar, Serv Dano Cerebral Hosp NISA, FIVAN, Valencia 46011, Spain
关键词
APOE; post-traumatic amnesia; traumatic brain injury; rehabilitation; memory; TRAUMATIC BRAIN-INJURY; APOLIPOPROTEIN-E POLYMORPHISM; HEAD-INJURY; ASSOCIATION; EPSILON-4; COGNITION; MODERATE; SCALE;
D O I
10.3109/02699051003724952
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: To determine if APOE genotype is linked to memory function after moderate-severe traumatic brain injury (TBI). Methods: Eighty-two patients in post-traumatic amnesia (PTA) and 107 patients who had emerged from PTA were selected from 239 consecutive patients admitted to the facility. Verbal memory assessments, including the Spanish version of the California Verbal Learning Test and the Working-Memory Index of the WAIS-III, were conducted immediately after PTA resolution or during the first week after admission for patients who were out of PTA. Both groups were reassessed 6 months after inclusion in a multidisciplinary rehabilitation programme. Results: Patients with the APOE-epsilon 4 allele (n = 17 in the PTA group and n = 9 in the out of PTA group) entered rehabilitation at a more impaired level, but made remarkable progress during follow-up. Fifty-five patients from the initial sample emerged from PTA during the follow-up period. Age, GOAT at admission and chronicity, but not APOE genotype or initial trauma severity, were significant predictors of emergence from PTA. Conclusions: APOE genotype seems to be associated with the trajectory of cognitive recovery after TBI, but does not play a determinant role in the efficacy of memory rehabilitation in this population.
引用
收藏
页码:886 / 892
页数:7
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