A Comparison of Pregnancy Outcomes in Patients Undergoing Donor Egg Single Embryo Transfers With and Without Preimplantation Genetic Testing

被引:22
作者
Masbou, Alexis K. [1 ]
Friedenthal, Jenna B. [2 ]
McCulloh, David H. [1 ]
McCaffrey, Caroline [1 ]
Fino, M. Elizabeth [1 ]
Grifo, James A. [1 ]
Licciardi, Frederick [1 ]
机构
[1] NYU Fertil Ctr, 660 First Ave,Fifth Floor, New York, NY 10016 USA
[2] NYU Langone Med Ctr, Obstet & Gynecol, New York, NY USA
关键词
oocyte donation; preimplantation genetic testing; infertility; LIVE BIRTH; ANEUPLOIDY; IMPLANTATION; CYCLES; OOCYTE; WOMEN; DNA; VITRIFICATION; MISCARRIAGE; DONATION;
D O I
10.1177/1933719118820474
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Two of the many milestone developments in the field of assisted reproduction have been oocyte donation and preimplantation genetic testing for aneuploidy (PGT-A). Because it has been demonstrated that even young women produce a meaningful proportion of aneuploid embryos, screening out such abnormalities could potentially increase the efficacy of donor egg (DE) cycles. In this retrospective cohort study, we investigated the effect of PGT-A on DE cycle outcomes, including implantation rate (IR), spontaneous abortion rate (SABR), and ongoing pregnancy/live birth rate. We used fresh and frozen donor cycles not using PGT-A as comparison groups; all cases involved single embryo transfer. Data analysis revealed that PGT-A did not improve pregnancy outcome metrics in DE cycles, although there was a trend toward decreasing the SABR. There was a significant increase in IR with fresh cycles outperforming all frozen cycles. Overall, these results suggest that the benefits of performing PGT-A on embryos derived from young DEs may be limited and that there is an effect of the freezing process on pregnancy outcomes. These findings may provide useful insights into the science and practice of PGT-A across all of its applications.
引用
收藏
页码:1661 / 1665
页数:5
相关论文
共 26 条
  • [1] Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF
    Baart, EB
    Martini, E
    van den Berg, I
    Macklon, NS
    Galjaard, RJH
    Fauser, BCJM
    Van Opstal, D
    [J]. HUMAN REPRODUCTION, 2006, 21 (01) : 223 - 233
  • [2] Impact of preimplantation genetic screening on donor oocyte-recipient cycles in the United States
    Barad, David H.
    Darmon, Sarah K.
    Kushnir, Vitaly A.
    Albertini, David F.
    Gleicher, Norbert
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2017, 217 (05) : 576.e1 - 576.e8
  • [3] Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotypes assessed using time-lapse imaging
    Barrie, Amy
    Homburg, Roy
    McDowell, Garry
    Brown, Jeremy
    Kingsland, Charles
    Troup, Stephen
    [J]. REPRODUCTIVE BIOMEDICINE ONLINE, 2017, 34 (05) : 455 - 462
  • [4] Differences in pregnancy outcomes in donor egg frozen embryo transfer (FET) cycles following preimplantation genetic screening (PGS): a single center retrospective study
    Coates, Alison
    Bankowski, Brandon J.
    Kung, Allen
    Griffin, Darren K.
    Munne, Santiago
    [J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2017, 34 (01) : 71 - 78
  • [5] Outcomes of IVF cycles coupled with PGS by aCGH of embryos from donor and autologous oocytes, transferred after vitrification to women of advanced maternal age
    Fedorova, Elena M.
    Shlykova, Svetlana A.
    Shunkina, Ksenia V.
    Zaitceva, Olga G.
    Lapina, Elena N.
    Yanchuk, Taras V.
    Kalugina, Alla S.
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 2017, 33 (09) : 737 - 740
  • [6] Development and validation of a next-generation sequencing-based protocol for 24-chromosome aneuploidy screening of embryos
    Fiorentino, Francesco
    Biricik, Anil
    Bono, Sara
    Spizzichino, Letizia
    Cotroneo, Ettore
    Cottone, Giuliano
    Kokocinski, Felix
    Michel, Claude-Edouard
    [J]. FERTILITY AND STERILITY, 2014, 101 (05) : 1375 - U41
  • [7] Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates
    Forman, E. J.
    Tao, X.
    Ferry, K. M.
    Taylor, D.
    Treff, N. R.
    Scott, R. T.
    [J]. HUMAN REPRODUCTION, 2012, 27 (04) : 1217 - 1222
  • [8] Comparative genomic hybridization of oocytes and first polar bodies from young donors
    Fragouli, E.
    Escalona, A.
    Gutierrez-Mateo, C.
    Tormasi, S.
    Alfarawati, S.
    Sepulveda, S.
    Noriega, L.
    Garcia, J.
    Wells, D.
    Munne, S.
    [J]. REPRODUCTIVE BIOMEDICINE ONLINE, 2009, 19 (02) : 228 - 237
  • [9] The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening
    Franasiak, Jason M.
    Forman, Eric J.
    Hong, Kathleen H.
    Werner, Marie D.
    Upham, Kathleen M.
    Treff, Nathan R.
    Scott, Richard T., Jr.
    [J]. FERTILITY AND STERILITY, 2014, 101 (03) : 656 - +
  • [10] Exploratory bioinformatics investigation reveals importance of "junk" DNA in early embryo development
    Ge, Steven Xijin
    [J]. BMC GENOMICS, 2017, 18